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“The ubiquitin-proteasome system in genetic and obesity-linked immunometabolic disorders”

Colloquium in Pathophysiology, Infectiology and Immunologymore

 

Fantastische Bilanz des ICC Water & Health bei der 37. Jahrestagung der ÖGHMP

Nach CoVID-19 bedingter zweimaliger Absage und mit zweijähriger Verspätung konnte die 37. Jahrestagung der ÖGHMP (Österr. Gesellschaft für Hygiene, Mikrobiologie und Präventivmedizin) vom 31. Mai bis 2. Juni in Bad Ischl endlich...more

 

Oct. 11, 2021: Research for our drinking water

The Inter-University Cooperation Center for Water and Health (ICC Water & Health), in which Regina Sommer and Alexander Kirschner from our institute as well as the Vienna University of Technology and the Karl Landsteiner Private...more

 

Oct. 1, 2021: Trend magazine elected René Platzer, BSc MSc PhD as its next generation top researcher

To the press release more

 

Sept. 17, 2021: 'EFIS Best Poster Award'

Congratulations! Philipp Schatzlmaier, PostDoc at the Molecular Immunology Unit (HAI), won the 'EFIS Best Poster Award' at the 6th European Congress of Immunology, taking place September 1st to 4th. He was selected as one of...more

 

Sept. 14, 2021: Venugopal Gudipati was selected to give a talk in the Bright Sparks session at the European Congress of Immunology (ECI) 2021.

At the 6th European Congress of Immunology, held online from September 1 – 4, 2021, Venugopal Gudipati (HAI) from the Institute for Hygiene and Applied Immunology (HAI), was selected as one of the 24 Bright Sparks out of the...more

 

Sept. 3, 2021: Water hygiene department

is now the test center of the Austrian Association for Gas and Water ("ÖVGW")more

 

August 2, 2021: MedUni Wien "Researcher of the Month" August 2021, René Platzer, BSc MSc PhD

The “Researcher of the Month” jury gives the award for this month to René Platzer on the occasion of the work published in the top journal “Nature Communications” (IF 13.610) „Unscrambling fluorophore blinking for comprehensive...more

 

Poster price at the PhD Symposium 2021

Congratulation to Dr. Romana Klasinc and MSc. Carmen Rehm for their Poster price!more

 

MedUni Wien Researcher of the month, Mai 2021, Dr. Venugopal Gudipati

Inefficient CAR-proximal signaling blunts antigen detection.more

 

Honuring with the "Ehrennadel der Medizinischen Universität Wien"

On Friday , 2nd of October 2020 Prof. Dr. Hannes Stockinger and Univ. Prof. Dr. Gerhard Zalbinger were honoured by the Rector for their yearlong engagement and remarkable achievements for the Medical University with the...more

 

MedUni Wien "Researcher of the month", Juli 2020: Dr.in Sílvia Cervero-Aragó

Dr.in Sílvia Cervero-Aragó What are legionella bacteria, why can they become a problem and what can be done to prevent them from spreading? next...more

 

Empfehlungen zur Auswahl von Desinfektionsmitteln in Einrichtungen des Gesundheitswesens

Von Assoc. Prof. Dr. Miranda Suchomel, Institut für Hygiene und Angewandte Immunologiemore

 

Wie schütze ich mich am besten vor einer Ansteckung mit dem neuartigen Coronavirus SARS-CoV-2

Da noch keine Schutzimpfungen gegen SARS-CoV-2 existieren, stehen im Moment vor allem Hygienemaßnahmen zur Infektionsprävention im Vordergrund. more

 

Hannes Stockinger honored with Karl Landsteiner-Medal

At the annual meeting of the Austrian Society for Allergology and Immunology (ÖGAI) in Graz, Hannes Stockinger received the Karl Landsteiner-Medal for his merits for immunology, the highest immunological distinction awarded by...more

 

Markus Kraller wins Best Presentation Prize at Medical Postgraduate Conference

At the 16th International Medical Postgraduate Conference, held from 21 - 22 November 2019 in Hradec Králové, Czech Republic, Markus Kraller was awarded a Best Presentation Prizemore

 

Doctoral thesis completed: René Platzer

René Platzer, MSc, PhD – Molecular Immunology Unit – completed his doctoral thesis.more

 

Sílvia Cervero-Aragó wins Forum Water Hygiene Award

The Forum Water Hygiene awards the Science Prize 2018/19 for our latest work on the relevance of VBNC (viable but nonculturable) Legionella, which was recently published in the number 1 journal in the water sector "Water...more

 

Great success of the 20th symposium of the IWA Specialist Group Health-Related Water Microbiology in Vienna

The 20th symposium of the IWA Specialist Group Health-Related Water Microbiology, organized by ICC Water & Health and the Austrian Society for Hygiene, Microbiology and Preventive Medicine in Vienna (September 15–20, 2019, Campus...more

 

Great success for the 11th EFIS-EJI South Eastern European Immunology School (SEEIS2019)

At this year's summer school, held from 27 – 30 September 2019 in Pristina, Kosovo, 65 participants from 15 countries, especially from Eastern Europe, could benefit from lectures and workshops in basic and clinical immunology.more

 
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Inhaltsbereich

Peptide inhibits tumor growth

(Vienna, 14-02-2011) In a recent study Dr. Vladimir Leksa from the Molecular Immunology Unit of the Institute for Hygiene and Applied Immunology of the Center for Pathophysiology, Infectiology and Immunology describes a particular peptide via which he can inhibit migration of cancer cells. This allows new approaches for cancer therapy. The work was recently published in the prestigious scientific journal Circulation Research.


For some cells, it is necessary to migrate within the body. This applies, for example, for angiogenic endothelial cells or immune cells the latter for detecting intruders as well as tumor cells to defense the body. Tumor cells often employ the same mechanism as these cells or “hijack" them to penetrate tissues and form metastases. A major component of this migration mechanism is the urokinase plasminogen activator (uPA) and a specific receptor (sM6P/IGF2R, CD222) that regulates the functions of uPA.

In an interdisciplinary study, Dr. Vladmir Leksa has now shown that by means of a peptide derived from M6P/IGF2R, he can selectively inhibit the uPA system. In in vitro tests not only the migration of angiogenic endothelial cells and the infiltration of cancer cells in artificial tissues was inhibited, but also in vivo in experimental animals the growth of human melanoma cells. This is the basis to develop new therapeutic approaches to suppress tumor growth and metastasis.

The work of Dr. Vladimir Leksa was performed in cooperation with the Center for Physiology and Pharmacology, the University Hospital of Dermatology and Internal Medicine I, Medical University of Vienna and the Institute of Molecular Biology, Slovak Academy of Sciences.

 

Inhibition of migration of endothelial cells (green) in an artificial tissue in the mouse by the M6P/IGF2R peptide (right) in comparison to a control peptide (left)

Publication in „Circulation Research“: Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation. Vladimir Leksa, Robert Loewe, Brigitte Binder, Herbert B. Schiller, Paul Eckerstorfer, Florian Forster, Ana Soler Cardona, Gabriela Ondrovičová, Eva Kutejová, Eva Steinhuber, Johannes Breuss, Johannes Drach, Peter Petzelbauer, Bernd R. Binder †, Hannes Stockinger doi: 10.1161/CIRCRESAHA.110.234732

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