Deutsche Version Deutsche Version
  MedUni Vienna    Intranet    MedUni Vienna - Shop    University Library    University Hospital Vienna  
 
cepii_hygiene_EN.png
 
 
 
Hauptnavigation
  • Home
  • General Information
  • Health-related issues
  • Teaching
  • Research
  • News data
 
hai /
 
Subnavigation

News

 

“The ubiquitin-proteasome system in genetic and obesity-linked immunometabolic disorders”

Colloquium in Pathophysiology, Infectiology and Immunologymore

 

Fantastische Bilanz des ICC Water & Health bei der 37. Jahrestagung der ÖGHMP

Nach CoVID-19 bedingter zweimaliger Absage und mit zweijähriger Verspätung konnte die 37. Jahrestagung der ÖGHMP (Österr. Gesellschaft für Hygiene, Mikrobiologie und Präventivmedizin) vom 31. Mai bis 2. Juni in Bad Ischl endlich...more

 

Oct. 11, 2021: Research for our drinking water

The Inter-University Cooperation Center for Water and Health (ICC Water & Health), in which Regina Sommer and Alexander Kirschner from our institute as well as the Vienna University of Technology and the Karl Landsteiner Private...more

 

Oct. 1, 2021: Trend magazine elected René Platzer, BSc MSc PhD as its next generation top researcher

To the press release more

 

Sept. 17, 2021: 'EFIS Best Poster Award'

Congratulations! Philipp Schatzlmaier, PostDoc at the Molecular Immunology Unit (HAI), won the 'EFIS Best Poster Award' at the 6th European Congress of Immunology, taking place September 1st to 4th. He was selected as one of...more

 

Sept. 14, 2021: Venugopal Gudipati was selected to give a talk in the Bright Sparks session at the European Congress of Immunology (ECI) 2021.

At the 6th European Congress of Immunology, held online from September 1 – 4, 2021, Venugopal Gudipati (HAI) from the Institute for Hygiene and Applied Immunology (HAI), was selected as one of the 24 Bright Sparks out of the...more

 

Sept. 3, 2021: Water hygiene department

is now the test center of the Austrian Association for Gas and Water ("ÖVGW")more

 

August 2, 2021: MedUni Wien "Researcher of the Month" August 2021, René Platzer, BSc MSc PhD

The “Researcher of the Month” jury gives the award for this month to René Platzer on the occasion of the work published in the top journal “Nature Communications” (IF 13.610) „Unscrambling fluorophore blinking for comprehensive...more

 

Poster price at the PhD Symposium 2021

Congratulation to Dr. Romana Klasinc and MSc. Carmen Rehm for their Poster price!more

 

MedUni Wien Researcher of the month, Mai 2021, Dr. Venugopal Gudipati

Inefficient CAR-proximal signaling blunts antigen detection.more

 

Honuring with the "Ehrennadel der Medizinischen Universität Wien"

On Friday , 2nd of October 2020 Prof. Dr. Hannes Stockinger and Univ. Prof. Dr. Gerhard Zalbinger were honoured by the Rector for their yearlong engagement and remarkable achievements for the Medical University with the...more

 

MedUni Wien "Researcher of the month", Juli 2020: Dr.in Sílvia Cervero-Aragó

Dr.in Sílvia Cervero-Aragó What are legionella bacteria, why can they become a problem and what can be done to prevent them from spreading? next...more

 

Empfehlungen zur Auswahl von Desinfektionsmitteln in Einrichtungen des Gesundheitswesens

Von Assoc. Prof. Dr. Miranda Suchomel, Institut für Hygiene und Angewandte Immunologiemore

 

Wie schütze ich mich am besten vor einer Ansteckung mit dem neuartigen Coronavirus SARS-CoV-2

Da noch keine Schutzimpfungen gegen SARS-CoV-2 existieren, stehen im Moment vor allem Hygienemaßnahmen zur Infektionsprävention im Vordergrund. more

 

Hannes Stockinger honored with Karl Landsteiner-Medal

At the annual meeting of the Austrian Society for Allergology and Immunology (ÖGAI) in Graz, Hannes Stockinger received the Karl Landsteiner-Medal for his merits for immunology, the highest immunological distinction awarded by...more

 

Markus Kraller wins Best Presentation Prize at Medical Postgraduate Conference

At the 16th International Medical Postgraduate Conference, held from 21 - 22 November 2019 in Hradec Králové, Czech Republic, Markus Kraller was awarded a Best Presentation Prizemore

 

Doctoral thesis completed: René Platzer

René Platzer, MSc, PhD – Molecular Immunology Unit – completed his doctoral thesis.more

 

Sílvia Cervero-Aragó wins Forum Water Hygiene Award

The Forum Water Hygiene awards the Science Prize 2018/19 for our latest work on the relevance of VBNC (viable but nonculturable) Legionella, which was recently published in the number 1 journal in the water sector "Water...more

 

Great success of the 20th symposium of the IWA Specialist Group Health-Related Water Microbiology in Vienna

The 20th symposium of the IWA Specialist Group Health-Related Water Microbiology, organized by ICC Water & Health and the Austrian Society for Hygiene, Microbiology and Preventive Medicine in Vienna (September 15–20, 2019, Campus...more

 

Great success for the 11th EFIS-EJI South Eastern European Immunology School (SEEIS2019)

At this year's summer school, held from 27 – 30 September 2019 in Pristina, Kosovo, 65 participants from 15 countries, especially from Eastern Europe, could benefit from lectures and workshops in basic and clinical immunology.more

 
Displaying results 1 to 20 out of 103
<< First < Previous Page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Next > Last >>
 
Inhaltsbereich

August 2, 2021: MedUni Wien "Researcher of the Month" August 2021, René Platzer, BSc MSc PhD

The “Researcher of the Month” jury gives the award for this month to René Platzer on the occasion of the work published in the top journal “Nature Communications” (IF 13.610) „Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy“.

René Platzer, BSc MSc PhD

The present study was carried out as a multidisciplinary project between the research groups of Assoc. Prof. Dr. Johannes Huppa at the Institute for Hygiene and Applied Immunology at the Medical University of Vienna and Univ.-Prof. Dr. Gerhard Schütz at the Institute for Applied Physics at the Technical University of Vienna.

How to outsmart the laws of nature - but not entirely

High-resolution fluorescence microscopy (or super-resolution microscopy) is used all over the world today to make the smallest structures on a cell visible and to understand the interaction of molecules on the cell surface. This technology actually contradicts a principle that has long been considered a law of nature: With light waves you can only image objects that are larger than half the light wavelength. This rule is true, but it can be outwitted if different points on the object are illuminated one after the other over a longer period of time - for example fluorescence-marked molecules on the cell surface. The Nobel Prize in Chemistry was awarded in 2014 for this basic idea of ​​super-resolution microscopy. Since then, this microscopy technique has proven itself time and again all over the world. But a team of scientists at the Medical University of Vienna and TU Vienna have now shown that high-resolution (super-resolution) images are often deceptive and that one has to be very careful when interpreting the data. Although super-resolution microscopy makes individual molecules visible, it can easily happen that a molecule is imaged several times. A simple multiple exposure can then be mistaken for a cluster of several molecules [5]. René Platzer worked closely with Dr. Benedikt Rossboth and Dr. Mario Brameshuber developed a method to differentiate between these two possibilities.

In addition, with this improved technology, the researchers were able to show once again that the highly sensitive antigen receptors on a T cell do not occur in enriched groups, as was first assumed, but are distributed randomly on the cell surface [1,2]. As an important part of our immune system, T cells react to an extremely small number of certain antigens that are on the surface of antigen-presenting cells [3]. The theory persisted for a long time that antigen receptors on the T-cell surface are locally enriched in small groups (clusters) in order to make the T-cells more sensitive for the recognition of antigens. The new results contradict this theory and point to the possibility that the visible clusters are complex image artifacts and that individual receptors are actually randomly distributed on the cell surface, presumably to enable accelerated scanning of antigen-presenting cells [2,3,4] .

With the help of high-resolution fluorescence microscopy, René Platzer and his colleagues hope to gain further deep insights into the biophysical principles of T-cell antigen recognition, above all to understand this highly sensitive and vital process down to the smallest detail. This technology and the knowledge gained from it form an important basis for future projects with partners from medicine, research and industry, which aim to establish more effective immunotherapies.

Scientific environment

Over the years, René Platzer's scientific work has been shaped by an extremely interdisciplinary research environment. At the Institute of Hygiene and Applied Immunology in the laboratory of Assoc. Prof. Dr. Johannes Huppa and Univ.-Prof Dr. Hannes Stockinger, he played a decisive role in setting up the infrastructure for protein biochemistry and high-resolution fluorescence microscopy. René Platzer is in constant contact with the research group of Univ.-Prof. Dr. Gerhard Schütz at the Institute for Applied Physics at the Technical University of Vienna. This intensive and long-term collaboration resulted in several publications that mainly dealt with the biophysical basis of T cell antigen recognition (Hellmeier et al. 2021 PNAS, Göhring et al. 2021 Nature Communications, Rossboth et al. 2018 Nature Immunology and Varadi et al. 2019 Biophysical Journal). In addition, he was involved with considerable interest and scientific enthusiasm in numerous projects within the Medical University of Vienna (Ohradanova-Repic et al. 2018 Frontiers in Immunology, Kumar et al. 2015 Biomedical Optics Express and Hamminger et al. 2021 Journal of Autoimmunity), of the St. Anna Children's Cancer Research Institute (Salzer et al. 2016 Nature Immunology and Salzer et al. 2020 Science Immunology), as well as international collaborations (Jongsma et al. 2020 Immunity). Many of the extremely exciting cross-institute and cross-border collaborations resulted in publications in renowned specialist journals.

To person

René Platzer graduated from the Bundesgymnasium and Bundesrealgymnasium Leibnitz in 2007 and studied molecular biology at the Karl-Franzens-University Graz and the Technical University Graz. After completing his bachelor's degree and a 3-month internship at the University of Zurich, he studied immunology and molecular microbiology at the University of Vienna. At the end of his master's degree, René Platzer completed two summer schools with a focus on biomedical microscopy and high-resolution microscopy at the ETH Zurich and at the Swammerdam Institute for Life Sciences in Amsterdam, which from now on shaped his scientific work. René Platzer worked in the laboratory of Assoc. Prof. Dr. Johannes Huppa and Univ.- Prof. Dr. Hannes Stockinger at the Institute for Hygiene and Applied Immunology and dealt with the question of how certain processes of T cell antigen recognition take place at the molecular level. In the course of his dissertation, René Platzer dealt with the biophysical principles of antigen presentation and the associated T-cell activation and played a key role in the development of new analysis methods for high-resolution fluorescence microscopy. As a doctoral student, René Platzer took part in the international PhD program “Cell Communication in Health and Disease” (CCHD) and received a renowned and highly competitive PhD grant from the Boehringer Ingelheim Fund. He attended numerous national and international conferences at which he also won prizes for the presentation of his scientific results.

After completing his PhD studies, René Platzer continues his scientific work at the Medical University of Vienna as a collaborator in a research collaboration between Assoc. Prof. Dr. Johannes Huppa and Boehringer Ingelheim RCV continued. In this project he characterizes various BiTE antibodies (bispecific T-cell engagers) with regard to their potential for T-cell activation and initiation of an immune response. He researches how natural T cell antigen recognition processes differ from therapeutic approaches such as BiTE antibodies or CAR T cells (chimeric antigen receptor T cells) in order to support the development of effective BiTE antibodies for cancer therapy.

Selected literature

  1. Platzer R*, Rossboth BK*, Schneider MC, Sevcsik E, Baumgart F, Stockinger H, Schütz GJ, Huppa JB+, and Brameshuber M+. 2020. Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy. Nature Communications. 11:4993. *equal contribution, +corresponding author
  2. Rossboth B, Arnold AM, Ta H, Platzer R, Kellner F, Huppa JB, Brameshuber M+, Baumgart F+, and Schütz GJ+. 2018. TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells. Nature Immunology. 19:821-827. +corresponding author
  3. Platzer R and Huppa JB. T-cell Antigen Recognition – Lessons from the Past and Projections into the Future. 2020. Encyclopedia of Life Sciences (eLS). John Wiley & Sons, Ltd: Chichester. doi: 10.1002/9780470015902.a0001229.pub3.
  4. Brameshuber, M, Kellner F*, Rossboth BK*, Ta H, Alge K, Sevcsik E, Göhring J, Axmann M, Baumgart F, Gascoigne NRJ, Davis SJ, Stockinger H, Schütz GJ, and Huppa JB+. 2018. Monomeric TCRs drive T cell antigen recognition. Nature Immunology. 19:487-496. *equal contribution, +corresponding author
  5. Baumgart F, Arnold AM, Rossboth BK, Brameshuber M, and Schütz GJ+. 2018. What we talk about when we talk about nanoclusters. Methods and Applications in Fluorescence. 7:013001. +corresponding author
back to: Institute for Hygiene and Applied Immunology
 
 
Drucken
 

Quick Links

 
-- Head of Institute/ Secretarial office
-- Test results and sample retrieval
-- News Archive
-- Events
-- Intranet Login
-- Jobs
 
 

Featured

 
 
 
 
 
 
 
© MedUni Wien  | 
 Publishing information | Terms of use | Data Protection | Accessibility |Contact