Michael Duchêne studied Chemistry in Freiburg (1972-1974), Southampton (1974-1975) and Munich (1975-1978). From 1976, he studied Chemistry and Medicine in parallel. In the studies of Chemistry, he specialised on Biochemistry. In 1978 he obtained his Diploma for Chemistry and in 1984 he finished his PhD thesis entitled "The expression of genes encoding collagen in embryonal chondrocytes. The work had been carried out at the Department of Connective Tissue Research (Head: Prof. Dr. Klaus Kühn) at the Max-Plack-Institute of Biochemistry, Martinsried.
From 1984-1989, Michael Duchêne was postdoc at the "Laboratorium fur Molekulare Biologie, Genzentrum", University of Munich, working on active and passive immunisation against Pseudomonas aeruginosa, in addition on in vitro splicing in Saccharomyces cerevisiae.
In 1989, Michael Duchêne moved to what was then the Institute of Specific Prophylaxis and Tropical Medicine of the University of Vienna (Head: Prof. Dr. Gerhard Wiedermann), where he has since worked with a small team on the molecular biology, proteomics and biochemistry of Entamoeba histolytica. In 1993 he was granted the "venia docendi" for the field of Molecular Microbiology. A second major research project was the molecular characterisation of pollen and indoor allergens.
Michael Duchêne is member of several scientific societies, has been reviewer for more than 30 journals and grant organisations. Members of the team have been awarded several prizes. In total, the work has been presented in more than 80 full publications and by more than 220 presentations at national and international conferences.