Cardiology; Mitral Valve Annuloplasty; Mitral Valve Insufficiency
My main research focus is to understand the cellular and molecular mechanisms involved in ischemic mitral regurgitation valvular and myocardal remodeling. The complex mechanical and flow forces generated during ischemic mitral regurgitation result in remodeling not only at the myocardial but also at the valvular level which mechanisms are still to be elucidated in order to be able to prevent its occurence.
Besides, relevant animal models of cardiovascular diseases using percutaneous techniques represents another research interest to test novel devices therapies (mitral repair systems, TAVI,...)
I also share the main research interest of the group: Cardioprotection strategies for myocardial remodeling after ischemia/reperfusion or myocardial infarction.
Techniques, methods & infrastructure
Swine and ovine models of ischemic mitral regurgitation and primary mitral regurgitation by chordal rupture involving Percutaneous techniques and contrast echocardiography.
Echocardiography: large animals (GE Vivid7 and Siemens Accuson2000) and small rodents (Visual Sonics Fujifilm 3100). Cardiac phenotype description and characterization of different extracardiac diseases (Liver cirrhosis, Duschene muscular dystrophy, Sarcoidosis,...)
In vitro techniques: Primary cell isolation, MACS, EMT in-vitro models