Costimulatory and Inhibitory T-Cell Receptors; Flow Cytometry; T-Lymphocytes, Regulatory; Translational Medical Research; Transplantation; Transplantation Chimera; Transplantation Immunology; Transplantation Tolerance
My main research interest is the role and potency of regulatory T cells (Tregs) in the induction and maintainance of transplantation tolerance.
The establishment of mixed hematopoietic chimerism is an exceptionally potent strategy for the induction of donor-specific tolerance in organ transplantation. We could show that Tregs improve chimerism induction in experimental animal models with reduced intensity conditioning. Moreover, adoptive Treg transfer induced intragraft regulatory mechanisms that prevent chronic rejection.
Currently, I am specifically interested in immunomodulation via interleukin/antibody complexes. By the use of specific IL2/anti-IL2 complexes, which induce selective expansion of Tregs, transplantation tolerance can be achieved.