Heavy Ion Radiotherapy; Immunotherapy; Organoids; Pancreatic Cancer; Radiation Oncology; Radioimmunotherapy; Radiotherapy; Spheroids, Cellular
My main research focus is the biology of ion beam therapy and to understand how the physical advantages of ion beam therapy can be exploited for an improved therapy response in patients. A specific aim is the conversion of immunologically cold (irresponsive) tumors, such as pancreatic cancer, into immunologically hot (responsive) tumors. Immune-evasion is significantly linked to the tumor microenvironment. To adress this important key aspect, heterotypic 3D tumor models, consisting of tumor as well as stromal components, are used.