Surgical Research Laboratories Head: Michael Bergmann Research Area: The task of the laboratory is to combine molecular/cellular biology and the needs posed by surgical patients. Thus, the laboratory acts at the interface between clinical medicine and basic research, promoting translational medical science. Members:
Immunohistology, including immunofluorescence microscopy and Fluorescence in situ hybridization (FISH)
FACS (including intracellular cytokine staining)
Cell isolation from various organs by flow cytometry (up to single-cell sorting) or microbeads
Cell culture and functional assays with low input cell numbers (including cytokine stimulation, proliferation assays, migration assays, cytotoxicity assays)
Single cell sequencing in cooperation with CeMM
Stary, V. et al., 2020. A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses. Science Immunology, 5(52), p.eaba6232. Available at: http://dx.doi.org/10.1126/sciimmunol.aba6232.
Stary, V. et al., 2020. Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer. Journal for ImmunoTherapy of Cancer, 8(2), p.e000667. Available at: http://dx.doi.org/10.1136/jitc-2020-000667.
Stary, V. & Stary, G., 2020. NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific? Frontiers in Cellular and Infection Microbiology, 10. Available at: http://dx.doi.org/10.3389/fcimb.2020.00208.
Malinowski, M. et al., 2015. Factors influencing hypertrophy of the left lateral liver lobe after portal vein embolization. Langenbeck’s Archives of Surgery, 400(2), pp.237–246. Available at: http://dx.doi.org/10.1007/s00423-014-1266-7.