Animals, Genetically Modified; Carcinoma, Non-Small-Cell Lung; Kirsten murine sarcoma virus; Molecular Targeted Therapy; Recombinant Proteins
My main research goal is modeling human diseases using genetically modified animals as tools. I have a strong expertise in the generation and characterization of transgenic mice (conditional knock-outs, knock-ins, BAC-based transgenic, etc.) mimicking human diseases with special emphasis in lung cancer. Currently, my research group is focused in three main topics:
1) Role of inflammation in KRAS driven lung adenocarcinomas.
2) Targeted and immune-therapies in lung adenocarcinomas .
3) Exploring the possibilities of using BAC-based expression vectors applied to mammalian (e.g. CHO-K1 cells) recombinant protein production, which could provide anti-cancer treatments, a collaborative project with POLYMUN Scientific Immunobiologische Forschung, an Austrian company in the field of recombinant protein production.