Apoptosis; Calcium Signaling; Melanoma, Experimental; Neuroblastoma; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Signalling by G protein-coupled receptors (GPCRs)
My current research focus covers pharmacological strategies to impair survival ov cancer cells, in particular melanoma and neuroblastoma . We try to understand the importantance of key nodes in signalling pathways as a prerequisit for elucidation of novel drug targets. Beside, we try to describe on molecular level drug side effects and drug resistance in order to contribute to enhanced drug safety.
We are also interested in the nucleotide NAADP, which is the most potent Ca2+ releaser.
Little is known about regulation of it´s synthesis and physiological signalling. We try to understand the role of NAADP signalling in skeletal and cardiac muscle.
Techniques, methods & infrastructure
A broad spectrum of techniques used in biochemical, cell biological and imaging research is performed. We are familiar with enzyme kinetics, ligand binding studies and chemical modification of proteins and delineation of signaling pathways. As a source for these analyses we use material from cell lines, primary cells and tissue from in vivo model organisms.