Amino Acids, Peptides, and Proteins; Ant Venoms; Arginine Vasopressin; Cyclotides; Drug Design; Molecular Pharmacology of Bioactive Peptides from Nature; Multiple Sclerosis; Neuropeptides; Oxytocin; Receptors, Opioid, kappa; Scorpion Venoms; Signalling by G protein-coupled receptors (GPCRs)
Study of molecular mechanisms in living organisms by employing a toolbox of nature-derived and synthetically optimized compounds with biological activity to be analyzed in vitro and in vivo. The research includes the isolation, design and synthesis of biologically active peptides which will be useful for drug discovery or as diagnostic tools.
Techniques, methods & infrastructure
chemical extraction, UPLC/HPLC, peptide synthesis, lyophilization, mass spectrometry, MALDI-TOF/TOF, MALDI imaging, LC-MS/MS, proteomics, peptidomics, transcriptome analysis, insect rearing, GPCR signalling, second messenger analysis (cAMP, IP1, ERK, Ca2+), immunohistochemistry, Western blotting, Molecular Biology