Amino Acids, Peptides, and Proteins; Cyclotides; Molecular Pharmacology of Bioactive Peptides from Nature; Proteomics
My main research focus is to understand the importance of natural bioactive peptide from plants and their application to modulate molecular receptors and enzymes. The research is designed to elucidate molecular mechanisms of bioactive circular cystine-rich peptides such as immune system modulation and to understand the underlying effects. Natural bioactive peptide ligands are identified using a bioassay-guided fractionation and their structure-function and bioactivity-structure relationship are studied by applying chemical synthesis and activity assignments. Promising ligand peptideds are improved to provide future drug candidates.
Techniques, methods & infrastructure
Mass spectrometry based proteomics and peptidomics using MALDI-TOF/TOF-MS and LC-MS/MS; Peptide chemical Biology, G-protein coupled receptor pharmacology, Peptide Bioactivity-Structure relationship studies, Functional protein expression, protease inhibition assays.