Blood Platelets; Hemic and Immune Systems; Thrombosis
We are interested in the physiological and pathophysiological roles of platelets in inflammation, infection and tissue regeneration. Platelets are circulating anucleate blood cells that have a critical function in haemostasis by facilitating the cessation of bleeding. In recent years it became increasingly apparent that platelets are not only important in haemostasis and thrombosis, but they can also fine-tune immune responses as well as tissue repair processes. Upon activation platelets release the content of their granules, which contain a plethora of downstream effector molecules that can modulate leukocyte and endothelial cell functions. These include cytokines and chemokines, coagulation factors and fibrinolytic agents, as well as regulators of angiogenesis. Our group investigates the immunomodulatory role of platelets in acute and chronic inflammation and infection, the mechanism of platelet-mediated tissue regeneration and the impact of antiplatelet therapies in this context. Moreover we focus on novel biomarker development to predict disease progression in cardiovascular and liver diseases, cancer and sepsis.