Keywords

Autoimmune Diseases; Biology; Clinical Immunology; Innate Immunity; Molecular Biology

Research group(s)

• Gernot Schabbauer

Research interests

Our research is focused on phospholipid signal transduction and its contribution in myeloid cell biology in the context of acute and chronic inflammatory diseases. 

Techniques, methods & infrastructure

To achieve our research goals we make use of a variety of different genetically modified mice. These strains are then subjected to murine models of autoimmunity, acute and chronic inflammation. To visualize inflammatory processes in living organisms, we use an IVIS small animal imaging system. Further analyses, such as functional assays, FACS and transcriptomics are done mainly on sorted myeloid cells, such as macrophages and dendritic cells, derived directly from the animals.

Selected publications

1. Sahin, E. et al., 2015. Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. The Journal of Immunology, 195(6), pp.2560-2570. Available at: http://dx.doi.org/10.4049/jimmunol.1402511.
2. Sahin, E. et al., 2014. Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses. The Journal of Immunology, 193(4), pp.1717-1727. Available at: http://dx.doi.org/10.4049/jimmunol.1302167.
3. Bluml, S. et al., 2013. Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells. Annals of the Rheumatic Diseases, 74(1), pp.227-233. Available at: http://dx.doi.org/10.1136/annrheumdis-2013-203486.
4. Gunzl, P. et al., 2010. Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation. Journal of Leukocyte Biology, 88(6), pp.1259-1269. Available at: http://dx.doi.org/10.1189/jlb.0110001.
5. Schabbauer, G. et al., 2010. Myeloid PTEN Promotes Inflammation but Impairs Bactericidal Activities during Murine Pneumococcal Pneumonia. The Journal of Immunology, 185(1), pp.468-476. Available at: http://dx.doi.org/10.4049/jimmunol.0902221.