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Gegründet im Jahr 1873
gehört das IPA zu den ältesten Forschungsinstituten der Medizinischen Universität Wien.
Derzeit haben wir 130 interdisziplinäre und internationale MitarbeiterInnen, deren Forschungsarbeit darauf abzielt, pathophysiologische Vorgänge besser zu verstehen und daraus innovative Konzepte zu entwickeln, die der Diagnose, Prophylaxe und Therapie von Erkrankungen dienen. Zusätzlich legen wir Wert auf höchste Qualität in der Lehre und Ausbildung von MedizinerInnen und NaturwissenschafterInnen. Darüber hinaus bietet das IPA die postgradualen
Ausbildungen zu FachärztInnen für Pathophysiologie und Immunologie an.

Research News

 
   

The preclinical data for a vaccine developed at MedUni Vienna to protect against SARS-CoV-2 indicates that it is effective against all SARS-CoV-2 variants known to date, including omicron - even in those who have not yet built up any immunity as a result of vaccination (non-responders). The data from the study were recently published in the leading journal "Allergy".

 
 

Schmalz S, Mayr V, Shosherova A, Gepp B, Ackerbauer D, Sturm G, Bohle B, Breiteneder H, Radauer C. Isotype-specific binding patterns of serum antibodies to multiple conformational epitopes of Bet v 1.

 
 

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 
 

Martin Schepelmann, Nadja Kupper, Marta Sladczyk, Bethan Mansfield, Teresa Manhardt, Karina Piatek, Luca Iamartino, Daniela Riccardi, Benson M. Kariuki, Marcella Bassetto, and Enikö Kallay Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells Int. J. Mol. Sci. 2021, 22(18), 10124; https://doi.org/10.3390/ijms221810124

 
 

Foot ulcer is a common complication of diabetes mellitus; it is associated with substantial morbidity and mortality and remains a major risk factor for lower leg amputation. Extracting accurate morphological features from the foot wounds is crucial for proper treatment. Computer-mediated approaches enable segmentation of the lesions and extraction  of related morphological features. Deep learning-based methods and more specifically convolutional neural networks (CNN) have shown excellent performances for various image segmentation tasks including medical image segmentation. In this work, Amirreza Mahbod, Rupert Ecker and Isabella Ellinger proposed an ensemble approach based on two encoder-decoder-based CNN models, namely LinkNet and UNet, to perform foot ulcer segmentation. Our method achieved the first rank in the FUSeg challenge leaderboard. Leaderboard link: https://uwm-bigdata.github.io/wound-segmentation/ Challenge link: https://fusc.grand-challenge.org/ Method description: https://arxiv.org/abs/2109.01408

 
 

News & Activities

 
   

Kürzlich wurden erstmals die 40 Österreichischen TopwissenschafterInnen im Fachgebiet Immunologie von Research.com veröffentlicht.

 
 

Isabella Ellinger and her collaboration partner Waranya Chatuphonprasert from Marasarakham University, Thailand, have contributed the chapter „Cholesterol and early development” to the first edition of the book “Cholesterol - From Chemistry and Biophysics to the Clinic” (2022, Elsevier, eBook ISBN: 9780323858588).

 
 

Sabine Flicker is the Head of Research Group “Antibody Research” at the Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna where she and her team work on the molecular, immunological and structural characterization of allergen-specific antibodies and nanobodies to develop antibody/nanobody-based treatment and prevention strategies for allergy.

 
 

Recently, Prof. Dr. Peter Pietschmann, head of the Division of Cellular and Molecular Pathophysiology and group leader of the “Bone Research Group” at the Institute of Pathophysiology and Allergy Research received not only one, but two FWF grants (Austrian Science Funds).

 
 

Diana Mechtcheriakova, Assoc. Prof., Priv. Doz., Dr., Dipl.-Ing. is the Head of Research Group “Molecular Systems Biology and Pathophysiology” at the Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, the Head of Systems Medicine subdivision of the Austrian Platform for Personalized Medicine, and the Head of technology subunit Tissue Image Cytometry at the BioImaging Austria.