Recent publication of the research team of Diana Mechtcheriakova has been featured by Global Medical Discovery
The Global Medical Discovery, a Canadian organization that publishes a selected list of globally significant patents, discoveries and publications, has listed a recent article of Diana Mechtcheriakova and research team in collaboration with Erika Jensen-Jarolim entitled " Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer" published in Cancer Immunol Immunother as one of the Key scientific articles.
Link to the Global Medical Discovery
Activation-induced cytidine deaminase (AID) is critically involved in class switch recombination and somatic hypermutation of Ig loci resulting in diversification of antibodies repertoire and as such represents a physiological tool to introduce DNA alterations. Revolutional last year findings indicate that under pathophysiological conditions AID can target non-Ig genes within genomic DNA. Furthermore, AID is now considered as potential bridging factor linking genetic and epigenetic programs. The article gives an integrated overview on AID-driven biological processes and describes the multigene signature approach followed by creation of AID-associated functional gene network to address the pathogenic potential of AID linking inflammation, aberrant immunity and cancer. Strong advantage of the proposed approach is the validation of in silico-derived gene networks - either pathway- or disease-associated - using the high sensitivity and reproducibility of real-time PCR-based assay allowing quantitative profiling of low-copy genes, splice variants, and homologous gene family members. Importantly, identification and validation of multigene signatures covering potential AID-driven mechanism(s) which strongly contribute to disease development or resolution might have prognostic – which patient to treat – and/or predictive – what therapy to use – power and thereby be used for patient risk assessment.
Link to Molecular Systems Biology and Pathophysiology Group at IPA
Additional information about the Global Medical Discovery: Global Medical Discovery service alerts the scientific community to breaking journal articles considered to be of importance to the drug discovery process. Papers are selected from over 20,000 published each week from most peer reviewed journals. Global Medical Discovery is viewed almost 365,000 times each month by audience of academic and industrial R&D personnel and it is featured on the intranets of a growing number of the top 40 BioPharmaceutical companies and major academic institutions.
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