Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures.
Ursula Föger-Samwald1, Janina M. Patsch1,2, Doris Schamall1, Afarin Alaghebandan1, Julia Deutschmann1, Sylvia Salem3, Mehid Mousavi4, Peter Pietschmann1
Experimental Gerontology 57 (2014) 114-121. doi: 10.1016/j.exger.2014.05.014
Osteoporosis is extremely frequent in post-memopausal women. However, it is also a severe and frequently occurring but often underestimated disease in men. There is increasing evidence to suggest that osteoporotic bone loss in male idiopathic osteoporosis and in age related osteoporosis is linked to osteoblast dysfunction rather than to increased osteoclast activity, as seen in postmenopausal women. In this paper we investigated bone microarchitectue and gene expression of osteoblast related genes in femoral heads and adjacent neck tissue from elderly osteoporotic men with hip fractures in comparison to men with osteoarthritis of the hip. Major microstructural changes in the trabecular structure associated with osteoporotic hip fractures in men were characterized by a significant decrease of bone volume and a significant increase of trabecular separation. Furthermore, we provide evidence for a significantly reduced expression of the main osteoblastic transcription factors RUNX2 and Osterix in men with hip fractures compared to men with osteoarthritis. With these data we strongly support the concept of osteoblast dysfunction as underlying pathophysiological mechanism of male osteoporosis.
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