EAACI Molecular Allergology User's Guide
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, Eigenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Węgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M.
Pediatr Allergy Immunol. 2016 May;27 Suppl 23:1-250. doi: 10.1111/pai.12563.
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Although the awareness of allergic diseases has steadily increased in the past, there is still a need for an improved personalized diagnosis and consequently an individualized management of the patient including preventive measures.
Therefore, the European Academy of Allergy and Clinical Immunology (EAACI) has started a project to translate up-to-date knowledge on molecular allergology into the best possible practice. The current knowledge on the molecular characteristics of allergens is already having a tremendous impact on our understanding of allergic sensitization, linked with different risks of symptom severity and the underlying immune mechanisms. Replacing allergen extracts by well-defined pure molecules provides a basis for the refined diagnosis of allergy and for an individualized management of the allergic patient.
With the contribution of four scientists from the Department of Pathophysiology and Allergy Research of the Medical University of Vienna, this publication offers a comprehensive overview of allergenic protein families, their characteristics, current applications and the advantages and limitations of this approach. This handbook of molecular allergology discusses the up-to-date diagnostic workup of allergic diseases including allergic reactions such as rhinoconjunctivitis, asthma to pollens, mites and additional airborne allergens, food allergies, atopic eczema, insect venom hypersensitivity and occupational allergies. The most important allergenic molecules inducing these diseases are covered in this handbook.
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