Bone effects of binge alcohol drinking
"Trabecular microarchitecture of the femur in a piglet"
Föger-Samwald U, Knecht C, Stimpfl T, Szekeres T, Kerschan-Schindl K, Mikosch P, Pietschmann P, Sipos W. Bone Effects of Binge Alcohol Drinking USing Prepubescent Pigs as a Model. Alcohol Clin Exp Res 2018; 42:2123-2135. Doi: 10.1111/acer.13874.
Chronic alcohol abuse in adults is associated with an elevated risk of osteoporotic fractures. Nevertheless, there is an important gap in our knowledge on bone health consequences of binge alcohol drinking in adolescents. In collaboration with the University of Veterinary Medicine Vienna, the Bone Research Group (Head: Peter Pietschmann) developed a model to study bone effects of binge alcohol drinking using prepubescent pigs. Piglets with a high propensity to drink alcohol were offered a mixture of hard liquor and apple juice two times a week; control piglets received apple juice in an identical manner. Blood alcohol concentrations were assessed to ensure that all piglets of the alcohol group fulfilled the criteria of binge drinking. Animals of the alcohol group demonstrated hypocalcemia, hypophosphatemia and site specific alterations of bone microarchitecture. Future studies in pigs will address the mechanisms of effects of binge alcohol drinking on bone and other organ systems.