The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer
The gut-associated lymphoid tissue represents an integral part of the immune system. Among the powerful players of the mucosa-associated lymphoid tissue are isolated lymphoid structures, ILSs. Additionally, in the course of cancer, ectopic lymphoid structures, ELSs, were shown to be formed at the tumor site. Both ILSs and ELSs act as multitasking information centers triggering multifaceted immune responses. An in-depth understanding of the complexity and functionality of ILSs and ELSs may lead to new directions in therapeutic interventions and/or provide help in treatment decisions as part of personalized medicine. The study recently published by researches from MSBP research group (Head: Diana Mechtcheriakova) and collaborative partners nominates ILSs as novel prognostic players orchestrating the pathobiology of metastatic colorectal cancer.
The authors implemented newly developed integrative strategy named DIICO/from Digital Immune Imaging to Clinical Outcome. DIICO is based on digital tissue image cytometry which enables to transform encrypted tissue information on immune cells and structures into numerical data for alignment with disease-relevant parameters. For that the computerized microscopy-based TissueFAXS platform was used and more than 550 tissue-derived data points were analyzed. Additive information was obtained by B-cell clonality assessment and a comprehensive analysis of Omics Data using GENEVESTIGATOR tool. The authors showed that the properties of specialized lymphoid structures, known as ILSs, in non-tumorous colon tissue predefine the immune phenotype of ectopic lymphoid structures formed at primary and distant metastatic sites. The major discovery is that B-cell-enriched and highly proliferative lymphoid structures are prognostic towards an improved clinical outcome for patients with metastatic colorectal cancer. The knowledge gained from this study expands our understanding of tumor-immune interactions and draws particular attention to the anti-tumor immune response guided by ILSs outside of tumor tissue.
“The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer.”
Mungenast, F.; Meshcheryakova, A.; Beer, A.; Salzmann, M.; Tamandl, D.; Gruenberger, T.; Pietschmann, P.; Koperek, O.; Birner, P.; Kirsch, I.; Robins, H.; Mittlboeck, M.; Jaritz, M.; Bergmann, M.; Zimmermann, P.; Mechtcheriakova, D. Cancers 2020, 12, 3117.