"Imaging Modalities for Biological and Preclinical Research: A Compendium", with unique, comprehensive collection of about 100 state-of-the-art imaging technologies.
Anastasia Meshcheryakova, Felicitas Mungenast and Diana Mechtcheriakova (Research Group Molecular Systems Biology and Pathophysiology, Department of Pathophysiology and Allergy Research, Medical University of Vienna) – experts in computerized microscopy and digital image analysis, and their collaborative partner Rupert Ecker (TissueGnostics, Austria) are proud to announce the publication of the book "Imaging Modalities for Biological and Preclinical Research: A Compendium", with unique, comprehensive collection of about 100 state-of-the-art imaging technologies. The Team of authors contributed with the chapter "Tissue Image Cytometry".
This chapter gives an in-depth introduction to tissue image cytometry, which can be seen as the next-generation digital imaging or digital pathology approach. It is highly complementary to the commonly used flow cytometry measurements for phenotyping at the single cell level, but applied to the intact tissue without need for a physical disintegration of tissue to a single cell level. The strength is based on the ability to convert the image data of a tissue specimen to numerical values in a patient-specific manner and thereby provide the quantitative insights into tissue architecture, cellular morphology as well as cell–cell interactions, adjusted to their localization in the context of complex tissue anatomy. This integrative technology provides a superior solution for a wide range of applications both in basic science and preclinical/clinical/translational research. Diana Mechtcheriakova and the Team describe herein the tissue image cytometry among the principal applications in the direction of personalized/precision medicine. The authors focus on promising diagnostic and therapeutic direction attributed to immuno-oncology and, more precisely, on lymphoid structures – the highly organized immune cell aggregates with active germinal centers – as markers of disease outcome.
Meshcheryakova, A., Mungenast, F., Ecker, R., & Mechtcheriakova, D. (2021). Tissue image cytometry. Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 1 (pp. I.2.h-1-I.2.h-10): IOP Publishing. doi.org/10.1088/978-0-7503-3059-6ch14