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Vaccine based on folded RBD-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variants

The preclinical data for a vaccine developed at MedUni Vienna to protect against SARS-CoV-2 indicates that it is effective against all SARS-CoV-2 variants known to date, including omicron - even in those who have not yet built up...[more]

 

Birch pollen allergic patients have IgE and IgG antibodies binding to diverse patterns of conformational epitopes on the major allergen, Bet v 1

Schmalz S, Mayr V, Shosherova A, Gepp B, Ackerbauer D, Sturm G, Bohle B, Breiteneder H, Radauer C. Isotype-specific binding patterns of serum antibodies to multiple conformational epitopes of Bet v 1.[more]

 

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M,...[more]

 

Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells

Martin Schepelmann, Nadja Kupper, Marta Sladczyk, Bethan Mansfield, Teresa Manhardt, Karina Piatek, Luca Iamartino, Daniela Riccardi, Benson M. Kariuki, Marcella Bassetto, and Enikö Kallay Stereo-Specific Modulation of the...[more]

 

Amirreza Mahbod, Post-Doc in the group of Isabella Ellinger, has achieved PLACE 1 in the leaderboard of the MICCAI 2021 Foot Ulcer Segmentation Challenge.

Foot ulcer is a common complication of diabetes mellitus; it is associated with substantial morbidity and mortality and remains a major risk factor for lower leg amputation. Extracting accurate morphological features from the...[more]

 

AID/APOBECs among important factors in body’s defence against SARS-CoV-2

Research team comprising Anastasia Meshcheryakova, Diana Mechtcheriakova and Peter Pietschmann from the Institute of Pathophysiology and Allergy Research has addressed the potential interrelations between AID/APOBECs and the...[more]

 

"Imaging Modalities for Biological and Preclinical Research: A Compendium", with unique, comprehensive collection of about 100 state-of-the-art imaging technologies.

Anastasia Meshcheryakova, Felicitas Mungenast and Diana Mechtcheriakova (Research Group Molecular Systems Biology and Pathophysiology, Department of Pathophysiology and Allergy Research, Medical University of Vienna) – experts in...[more]

 
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"Imaging Modalities for Biological and Preclinical Research: A Compendium", with unique, comprehensive collection of about 100 state-of-the-art imaging technologies.

Anastasia Meshcheryakova, Felicitas Mungenast and Diana Mechtcheriakova (Research Group Molecular Systems Biology and Pathophysiology, Department of Pathophysiology and Allergy Research, Medical University of Vienna) – experts in computerized microscopy and digital image analysis, and their collaborative partner Rupert Ecker (TissueGnostics, Austria) are proud to announce the publication of the book "Imaging Modalities for Biological and Preclinical Research: A Compendium", with unique, comprehensive collection of about 100 state-of-the-art imaging technologies. The Team of authors contributed with the chapter "Tissue Image Cytometry".

This chapter gives an in-depth introduction to tissue image cytometry, which can be seen as the next-generation digital imaging or digital pathology approach. It is highly complementary to the commonly used flow cytometry measurements for phenotyping at the single cell level, but applied to the intact tissue without need for a physical disintegration of tissue to a single cell level. The strength is based on the ability to convert the image data of a tissue specimen to numerical values in a patient-specific manner and thereby provide the quantitative insights into tissue architecture, cellular morphology as well as cell–cell interactions, adjusted to their localization in the context of complex tissue anatomy. This integrative technology provides a superior solution for a wide range of applications both in basic science and preclinical/clinical/translational research. Diana Mechtcheriakova and the Team describe herein the tissue image cytometry among the principal applications in the direction of personalized/precision medicine. The authors focus on promising diagnostic and therapeutic direction attributed to immuno-oncology and, more precisely, on lymphoid structures – the highly organized immune cell aggregates with active germinal centers – as markers of disease outcome.

Reference Source

https://iopscience.iop.org/book/978-0-7503-3059-6/chapter/bk978-0-7503-3059-6ch14

Meshcheryakova, A., Mungenast, F., Ecker, R., & Mechtcheriakova, D. (2021). Tissue image cytometry. Imaging Modalities for Biological and Preclinical Research: A Compendium, Volume 1 (pp. I.2.h-1-I.2.h-10): IOP Publishing. doi.org/10.1088/978-0-7503-3059-6ch14

 


 
 
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