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(01.04.2012) In einer im Topjournal Journal of Immunology veröffentlichten Studie konnten Beatrice Jahn-Schmid et al. das hohe allergene Potential von Ragweed- und Beifuß-Pollen auf immunologischer Ebene darstellen.

Im Spätsommer sind die aggressiven Pollen der Unkräuter Beifuß und Ragweed Hauptauslöser von Pollenallergien. [more]

 

(01.03.2012) Ein ForscherInnen-Team des Instituts für Pathophysiologie und Allergieforschung, hat herausgefunden, warum wir gegen Schnupfen nicht immun werden und ihn immer wieder bekommen können

Die im FASEB-Journal publizierte Studie von Katarzyna Niespodziana aus dem Team von Rudolf Valenta zeigt, dass die menschliche Immunabwehr gegen den Rhinovirus fehlgeleitet ist.[more]

 

(01.02.2012) Basophile sind keine Antigenpräsentierenden Zellen Publikation in der Fachzeitschrift „ALLERGY“

Human blood basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. Kitzmüller C, Nagl B, Deifl S, Walterskirchen C, Jahn-Schmid B, Zlabinger GJ, Bohle B. Allergy. 2011. [more]

 
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Inhaltsbereich

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. In this study, we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Specific antibody responses were directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

https://onlinelibrary.wiley.com/doi/10.1111/all.15066

 

 
 
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