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Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy

Rodríguez-Domínguez A, Berings M, Rohrbach A, Huang HJ, Curin M, Gevaert P, Matricardi PM, Valenta R, Vrtala S. Molecular Profiling of Allergen-Specific Antibody Responses May Enhance Success of Specific Immunotherapy. J Allergy...[more]

 

Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer

He S, Lyu F, Lou L, Liu L, Li S, Jakowitsch J, Ma Y.[more]

 

Transfer Learning Using a Multi-Scale and Multi-Network Ensemble for Skin Lesion Classification

A. Mahbod, G. Schaefer, Ch.Wang, G.Dorffner, R. Ecker, I. Ellinger [more]

 

A promising hypoallergen for immunotherapy of peanut allergy

Tscheppe A, Palmberger D, van Rijt L, Kalic T, Mayr V, Palladino C, Kitzmuller C, Hemmer W, Hafner C, Bublin M, van Ree R, Grabherr R, Radauer C, Breiteneder H: Development of a novel Ara h 2 hypoallergen with no IgE binding or...[more]

 

A Two-Stage U-Net Algorithm for Segmentation of Nuclei in H&E-Stained Tissues

Mahbod A., Schaefer G., Ellinger I., Ecker R., Smedby Ö., Wang C. (2019) In: Reyes-Aldasoro C., Janowczyk A., Veta M., Bankhead P., Sirinukunwattana K. (eds) Digital Pathology. ECDP 2019. Lecture Notes in Computer Science, vol...[more]

 

Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model

Samadi N, Klems M, Heiden D, Bauer R, Kitzmüller C, Weidmann E, Ret D, Ondracek AS, Duschl A, Horejs-Hoeck J, Untersmayr E. Allergy. 2019 Aug 24. doi: 10.1111/all.14030. PMID: 31444907[more]

 

Activated T cells enhance the antigen-presenting capacity of human neutrophils!

Samadi N, Polak D, Kitzmüller C, Steinberger P, Zlabinger GJ, Jahn-Schmid B, Bohle B. Eur J Immunol. 2019. doi: 10.1002/eji.201848057. PMID: 31332790 [more]

 
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Inhaltsbereich

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. In this study, we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Specific antibody responses were directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

https://onlinelibrary.wiley.com/doi/10.1111/all.15066

 

 
 
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