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In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

Sebastian Granitzer, Isabella Ellinger, Rumsha Khan, Katharina Gelles, Raimund Widhalm, Markus Hengstschläger, Harald Zeisler, Gernot Desoye, Lenka Tupova, Martina Ceckova, Hans Salzer, Claudia Gundacker Archives of Toxicology,...[more]

 

NSG mice humanized with allergen-specific T cell lines as in vivo model of respiratory allergy

Vizzardelli, C., F. Zimmann, B. Nagl, C. Kitzmüller, U. Vollmann, M. Gindl, S. Tangermann, B. Jahn-Schmid, L. Kenner, and B. Bohle. NSG mice humanized with allergen-specific T cell lines as in vivo model of respiratory allergy....[more]

 

The unique applicability of the human placenta to the Adverse Outcome Pathway (AOP) concept: the placenta provides fundamental insights into human organ functions at multiple levels of biological organisation

Claudia Gundacker and Isabella Ellinger Reproductive Toxicology, Volume 96, September 2020, Pages 273-281 [more]

 

Toward personalization of asthma treatment according to trigger factors

Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. While in the past few drugs for treatment of asthma were available, new treatment options are currently emerging which appear to...[more]

 

Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy

Rodríguez-Domínguez A, Berings M, Rohrbach A, Huang HJ, Curin M, Gevaert P, Matricardi PM, Valenta R, Vrtala S. Molecular Profiling of Allergen-Specific Antibody Responses May Enhance Success of Specific Immunotherapy. J Allergy...[more]

 

Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer

He S, Lyu F, Lou L, Liu L, Li S, Jakowitsch J, Ma Y.[more]

 

Transfer Learning Using a Multi-Scale and Multi-Network Ensemble for Skin Lesion Classification

A. Mahbod, G. Schaefer, Ch.Wang, G.Dorffner, R. Ecker, I. Ellinger [more]

 
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Inhaltsbereich

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. In this study, we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Specific antibody responses were directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

https://onlinelibrary.wiley.com/doi/10.1111/all.15066

 

 
 
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