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Neutrophile Granulozyten - „bad guys“ in der allergischen Spätreaktion

Erst kürzlich konnte Dominika Polak aus der Arbeitsgruppe „Allergieforschung“ unter der Leitung von Barbara Bohle zeigen, dass Neutrophile Granulozyten in der Spätphase (Entzündungsphase) der IgE-mediierten Allergie Eigenschaften...[more]

 

New stories from old bones

Citation: Nebot E, Heimel P, Tangl S, Dockner M, Patsch J, Weber GW, Pretterklieber M, Teschler-Nicola M, Pietschmann P. Paget’s disease of long bones: microstructural analyses of historical bone samples. Calcif Tissue Int 2019....[more]

 

Fusion proteins consisting of Bet v 1 and Phl p 5 form IgE-reactive aggregates with reduced allergenic activity

N. Najafi, G. Hofer, P. Gattinger, D. Smiljkovic, K. Blatt, A. Stöcklinger, W. Keller, P. Valent, J. Thalhamer, R. Valenta, S. Flicker., Scientific Reports, 9(1):4006. doi: 10.1038/s41598-019-39798-8. [more]

 

Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system

Terezia Kiskova, Yuliya Mytsko, Martin Schepelmann, Hanns Helmer, Renate Fuchs, Heidi Miedl, Christian Wadsack, Isabella Ellinger Placenta Volume 78, March 2019, Pages...[more]

 

Bone effects of binge alcohol drinking

Föger-Samwald U, Knecht C, Stimpfl T, Szekeres T, Kerschan-Schindl K, Mikosch P, Pietschmann P, Sipos W. Bone Effects of Binge Alcohol Drinking USing Prepubescent Pigs as a Model. Alcohol Clin Exp Res 2018; 42:2123-2135. Doi:...[more]

 

Neue Hoffnung für Menschen mit Fischallergie!

Fischallergie ist eine der gefährlichsten Nahrungsmittelallergien, da sie oft mit potenziell lebensbedrohenden Symptomen, wie zum Beispiel einem anaphylaktischen Schock, verbunden ist. Personen, die an Fischallergien leiden, sind...[more]

 

Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta

Waranya Chatuphonprasert1,2, Kanokwan Jarukamjorn3, and Isabella Ellinger1* 1Pathophysiology of the Placenta, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical...[more]

 
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Inhaltsbereich

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. In this study, we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Specific antibody responses were directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

https://onlinelibrary.wiley.com/doi/10.1111/all.15066

 

 
 
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