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Neue Hoffnung für Menschen mit Fischallergie!

Fischallergie ist eine der gefährlichsten Nahrungsmittelallergien, da sie oft mit potenziell lebensbedrohenden Symptomen, wie zum Beispiel einem anaphylaktischen Schock, verbunden ist. Personen, die an Fischallergien leiden, sind...[more]

 

Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta

Waranya Chatuphonprasert1,2, Kanokwan Jarukamjorn3, and Isabella Ellinger1* 1Pathophysiology of the Placenta, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical...[more]

 

Systems biology-based algorithm as novel approach in personalized medicine has recently been published by researches of Molecular Systems Biology and Pathophysiology Group (Head: Diana Mechtcheriakova) and collaborative partners.

Systems Biology book highlights the breakthroughs in analytical methods, advanced software, experimental devices, as well as integrative approaches for systems biology and systems medicine. [more]

 

Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion

Amirreza Mahbod, Isabella Ellinger, Rupert Ecker, Örjan Smedby, and Chunliang Wang Springer International Publishing AG, part of Springer Nature 2018 A. Campilho et al. (Eds.): ICIAR 2018, LNCS 10882, pp. 754–762, 2018....[more]

 

"Tag des Hundes“, 3. Juni 2018

Judit Fazekas-Singer aus dem Jensen-Jarolim Lab generierte in ihrer PhD Arbeit ein Immunglobulin der Klasse IgE, welches bei Hunden mit Krebserkrankung eingesetzt werden kann.[more]

 

Alum-adjuvanted allergoids induce functional blocking antibodies

Reithofer M, Böll SL, Kitzmüller C, Horak F, Sotoudeh M, Bohle B, Jahn-Schmid B. Clin Exp Allergy. 2018 Feb 12. doi: 10.1111/cea.13120[more]

 

Fusion proteins of flagellin and the major birch pollen allergen Bet v 1 show enhanced immunogenicity, reduced allergenicity, and intrinsic adjuvanticity.

Claudia Kitzmüller, Julia Kalser, Sonja Mutschlechner, Michael Hauser, Gerhard J. Zlabinger, Fatima Ferreira und Barbara Bohle J Allergy Clin Immunol. 2018 Jan;141(1):293-299.e6. [more]

 
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Inhaltsbereich

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. In this study, we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Specific antibody responses were directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

https://onlinelibrary.wiley.com/doi/10.1111/all.15066

 

 
 
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