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Interessante Neuigkeiten auf dem Gebiet AllergoOnkologie!

Mehrere MitarbeiterInnen des Instituts für Pathophysiologie und Allergieforschung sind an einem kürzlich erschienenen Positionspapier der EAACI TaskForce "AllergoOncology" beteiligt, die den aktuellen Wissensstand zum Thema...[more]

 

Characterization of the T cell response to Dau c 1, the Bet v 1-homolog in carrot.

Nora Zulehner, Birgit Nagl, Peter Briza, Anargyros Roulias, Barbara Ballmer-Weber, Gerhard J. Zlabinger, Fatima Ferreira und Barbara Bohle Allergy. 2017;72:244-251. doi: 10.1111/all.12938. Epub 2016 Jun 10. [more]

 

Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction

Pawel Dubiela, Roberta Aina, Dominika Polak, Sabine Geiselhart, Piotr Humeniuk, Barbara Bohle, Stefano Alessandri, Rebecca Del Conte, Francesca Cantini, Tomasz Borowski, Merima Bublin, Karin Hoffmann-Sommergruber Published...[more]

 

Successful collaboration of two IPA research groups and consolidation of knowledge from experts in the field of sphingolipid and bone research!

In the invited review article “Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential” recently published in Expert Opinion on Therapeutic Targets the authors – Anastasia...[more]

 

Estrogen-enhanced apical and basolateral secretion of apolipoprotein B-100 by polarized trophoblast-derived BeWo cells.

Kamper M, Mittermayer F, Cabuk R, Gelles K, Ellinger I, Hermann M. [more]

 

Passivrauchen: Acrolein hemmt Immunabwehr und kurbelt so Tumorwachstum an.

Allein in Österreich sterben zwei bis drei Personen täglich als Folge des Passivrauchens. Acrolein aus dem Seitenstromrauch hat nun Franziska Roth-Walter aus der Arbeitsgruppe Erika Jensen-Jarolim als Verursacher des Versagens...[more]

 

Die Darmbakterien-Zusammensetzung ist verantwortlich für Schutz vor einer Nahrungsmittelallergie-Entwicklung im experimentellen Modell.

In der jüngst in Clinical Immunology publizierten Studie konnte die Arbeitsgruppe um Dr. Susanne Diesner und Assoz. Prof. DDr. Eva Untersmayr-Elsenhuber in Kooperation mit PD DDr. Isabella Pali nachweisen, dass der Schutz gegen...[more]

 
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Inhaltsbereich

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. In this study, we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Specific antibody responses were directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

https://onlinelibrary.wiley.com/doi/10.1111/all.15066

 

 
 
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