MedUni Wien    Intranet    MedUni Wien - Shop    Universitätsbibliothek    Universitätsklinikum AKH Wien  
 
cepii_allergie.png
 
 
 
Hauptnavigation
  • Home
  • Allgemeine Informationen
  • Forschung
  • Studium & Lehre
  • FachärztInnenausbildung
 
IPA / Single View
 
Subnavigation

Research News

 

Estrogen-enhanced apical and basolateral secretion of apolipoprotein B-100 by polarized trophoblast-derived BeWo cells.

Kamper M, Mittermayer F, Cabuk R, Gelles K, Ellinger I, Hermann M. [more]

 

Passivrauchen: Acrolein hemmt Immunabwehr und kurbelt so Tumorwachstum an.

Allein in Österreich sterben zwei bis drei Personen täglich als Folge des Passivrauchens. Acrolein aus dem Seitenstromrauch hat nun Franziska Roth-Walter aus der Arbeitsgruppe Erika Jensen-Jarolim als Verursacher des Versagens...[more]

 

Die Darmbakterien-Zusammensetzung ist verantwortlich für Schutz vor einer Nahrungsmittelallergie-Entwicklung im experimentellen Modell.

In der jüngst in Clinical Immunology publizierten Studie konnte die Arbeitsgruppe um Dr. Susanne Diesner und Assoz. Prof. DDr. Eva Untersmayr-Elsenhuber in Kooperation mit PD DDr. Isabella Pali nachweisen, dass der Schutz gegen...[more]

 

Heat-labile Escherichia coli toxin enhances the induction of allergen-specific IgG antibodies in epicutaneous patch vaccination

C. R. Cabauatan1, R. Campana1, K. Niespodziana1, C. Reinisch2, U. Lundberg2, A. Meinke2, R. Henning3, A. Neubauer3 & R. Valenta1 1Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for...[more]

 

The Calcium-Sensing Receptor and the Reproductive System

Isabella Ellinger REVIEW ARTICLE Front. Physiol., 30 August 2016 [more]

 

AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer

Svoboda M, Meshcheryakova A, Heinze G, Jaritz M, Pils D, Castillo-Tong DC, Hager G, Thalhammer T, Jensen-Jarolim E, Birner P, Braicu I, Sehouli J, Lambrechts S, Vergote I, Mahner S, Zimmermann P, Zeillinger R and Mechtcheriakova...[more]

 

EAACI Molecular Allergology User's Guide

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA,...[more]

 
Displaying results 43 to 49 out of 94
<< First < Previous 4 5 6 7 8 9 10 Next > Last >>
 
Inhaltsbereich

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, Valenta R. Allergy. 2021 Aug 28. doi: 10.1111/all.15066. Online ahead of print.

 

The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. In this study, we analysed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Specific antibody responses were directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus-neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunisation with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity.

https://onlinelibrary.wiley.com/doi/10.1111/all.15066

 

 
 
Drucken
 

Schnellinfo

 
-- Green IPA
-- Technology Platforms
-- Kontakt
-- News (Archiv)
-- Seminare
-- Social Life
-- Intranet Login
-- QM-Dokumente (Intranet)
-- Bildergalerie (Intranet)
-- Alumni
-- Links
 
 

Featured

 
 
 
© MedUni Wien  | 
 Impressum | Nutzungsbedingungen | Datenschutzerklärung | Barrierefreiheit | Kontakt