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Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells

Martin Schepelmann, Nadja Kupper, Marta Sladczyk, Bethan Mansfield, Teresa Manhardt, Karina Piatek, Luca Iamartino, Daniela Riccardi, Benson M. Kariuki, Marcella Bassetto, and Enikö Kallay Stereo-Specific Modulation of the...[more]

 

Amirreza Mahbod, Post-Doc in the group of Isabella Ellinger, has achieved PLACE 1 in the leaderboard of the MICCAI 2021 Foot Ulcer Segmentation Challenge.

Foot ulcer is a common complication of diabetes mellitus; it is associated with substantial morbidity and mortality and remains a major risk factor for lower leg amputation. Extracting accurate morphological features from the...[more]

 

AID/APOBECs among important factors in body’s defence against SARS-CoV-2

Research team comprising Anastasia Meshcheryakova, Diana Mechtcheriakova and Peter Pietschmann from the Institute of Pathophysiology and Allergy Research has addressed the potential interrelations between AID/APOBECs and the...[more]

 

"Imaging Modalities for Biological and Preclinical Research: A Compendium", with unique, comprehensive collection of about 100 state-of-the-art imaging technologies.

Anastasia Meshcheryakova, Felicitas Mungenast and Diana Mechtcheriakova (Research Group Molecular Systems Biology and Pathophysiology, Department of Pathophysiology and Allergy Research, Medical University of Vienna) – experts in...[more]

 

IgE-cross-blocking antibodies to Fagales following sublingual immunotherapy with recombinant Bet v 1

João Rodrigues Grilo, Claudia Kitzmüller, Lorenz Aglas, Gabriela Sánchez Acosta, Ute Vollmann, Christof Ebner, Fritz Horak, Tamar Kinaciyan, Christian Radauer, Fatima Ferreira, Beatrice Jahn-Schmid, and Barbara Bohle Allergy....[more]

 

Amino Acid Transporter LAT1 (SLC7A5) Mediates MeHg-Induced Oxidative Stress Defense in the Human Placental Cell Line HTR-8/SVneo.

Granitzer S, Widhalm R, Forsthuber M, Ellinger I, Desoye G, Hengstschläger M, Zeisler H, Salzer H, Gundacker C. Amino Acid Transporter LAT1 (SLC7A5) Mediates MeHg-Induced Oxidative Stress Defense in the Human Placental Cell...[more]

 

The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

The gut-associated lymphoid tissue represents an integral part of the immune system. Among the powerful players of the mucosa-associated lymphoid tissue are isolated lymphoid structures, ILSs. Additionally, in the course of...[more]

 
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Inhaltsbereich

Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

Martin Schepelmann (group Enikö Kallay) and national and international colleagues and collaborators have just published a study in the Journal of the American Society of Nephrology (JASN), one of the highest ranked and most prestigious journals in the nephrology field.

The Calcium-Sensing Receptor (CaSR) is a protein which is best known for its role in maintaining mineral ion homeostasis in the blood. In this study, the role of this protein in blood vessels was investigated by characterizing a mouse in which the CaSR had been genetically deleted from vascular smooth muscle cells. They found that these mice suffer from a profound mineral ion imbalance, specifically hypercalcemia, hypercalciuria, and hyperphosphaturia. As kidney and parathyroid functions were normal, these results suggest a hitherto unknown mode how blood vessels contribute to mineral ion homeostasis control.

Schepelmann M, Ranieri M, Lopez-Fernandez I, Webberley TS, Brennan SC, Yarova PL, Graca J, Hanif UK, Müller C, Manhardt T, Salzmann M, Quasnichka H, Price SA, Ward DT, Gilbert T, Matchkov VV, Fenton RA, Herberger A, Hwong J, Santa Maria C, Tu CL, Kallay E, Valenti G, Chang W, Riccardi D. Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells. J Am Soc Nephrol. 2022 May 17:ASN.2021040585. doi: 10.1681/ASN.2021040585. Epub ahead of print. PMID: 35581010.

This work was supported by the European Commission Marie Curie Innovative Training Network Grant FP7-264663 “Multifaceted CaSR” (to D. Riccardi, S. Price, and E. Kallay), Austrian Science Fund Grant P-29948-B28 (to E. Kallay), Austrian Science Fund and Herzfelder’sche Familienstiftung Grant P-32840-B (to M. Schepelmann), “Intervento cofinanziato dal Fondo di Sviluppo e Coesione 2007-2013–APQ Ricerca Regione Puglia, Programma Regionale a Sostegno della Specializzazione Intelligente e della Sostenibilità Sociale ed Ambientale–FutureInResearch” CHVNKZ4 (to M. Ranieri), National Institutes of Health grants R01DK12165601 and R01DK122259, and Biomedical Laboratory Research and Development, VA Office of Research and Development grants I01BX005851 and 1IK6BX004835 (to W. Chang).

 
 
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