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Fusion proteins consisting of Bet v 1 and Phl p 5 form IgE-reactive aggregates with reduced allergenic activity

N. Najafi, G. Hofer, P. Gattinger, D. Smiljkovic, K. Blatt, A. Stöcklinger, W. Keller, P. Valent, J. Thalhamer, R. Valenta, S. Flicker., Scientific Reports, 9(1):4006. doi: 10.1038/s41598-019-39798-8. [more]

 

Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system

Terezia Kiskova, Yuliya Mytsko, Martin Schepelmann, Hanns Helmer, Renate Fuchs, Heidi Miedl, Christian Wadsack, Isabella Ellinger Placenta Volume 78, March 2019, Pages...[more]

 

Bone effects of binge alcohol drinking

Föger-Samwald U, Knecht C, Stimpfl T, Szekeres T, Kerschan-Schindl K, Mikosch P, Pietschmann P, Sipos W. Bone Effects of Binge Alcohol Drinking USing Prepubescent Pigs as a Model. Alcohol Clin Exp Res 2018; 42:2123-2135. Doi:...[more]

 

Neue Hoffnung für Menschen mit Fischallergie!

Fischallergie ist eine der gefährlichsten Nahrungsmittelallergien, da sie oft mit potenziell lebensbedrohenden Symptomen, wie zum Beispiel einem anaphylaktischen Schock, verbunden ist. Personen, die an Fischallergien leiden, sind...[more]

 

Physiology and pathophysiology of steroid biosynthesis, transport and metabolism in the human placenta

Waranya Chatuphonprasert1,2, Kanokwan Jarukamjorn3, and Isabella Ellinger1* 1Pathophysiology of the Placenta, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical...[more]

 

Systems biology-based algorithm as novel approach in personalized medicine has recently been published by researches of Molecular Systems Biology and Pathophysiology Group (Head: Diana Mechtcheriakova) and collaborative partners.

Systems Biology book highlights the breakthroughs in analytical methods, advanced software, experimental devices, as well as integrative approaches for systems biology and systems medicine. [more]

 

Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion

Amirreza Mahbod, Isabella Ellinger, Rupert Ecker, Örjan Smedby, and Chunliang Wang Springer International Publishing AG, part of Springer Nature 2018 A. Campilho et al. (Eds.): ICIAR 2018, LNCS 10882, pp. 754–762, 2018....[more]

 
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Inhaltsbereich

Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

Martin Schepelmann (group Enikö Kallay) and national and international colleagues and collaborators have just published a study in the Journal of the American Society of Nephrology (JASN), one of the highest ranked and most prestigious journals in the nephrology field.

The Calcium-Sensing Receptor (CaSR) is a protein which is best known for its role in maintaining mineral ion homeostasis in the blood. In this study, the role of this protein in blood vessels was investigated by characterizing a mouse in which the CaSR had been genetically deleted from vascular smooth muscle cells. They found that these mice suffer from a profound mineral ion imbalance, specifically hypercalcemia, hypercalciuria, and hyperphosphaturia. As kidney and parathyroid functions were normal, these results suggest a hitherto unknown mode how blood vessels contribute to mineral ion homeostasis control.

Schepelmann M, Ranieri M, Lopez-Fernandez I, Webberley TS, Brennan SC, Yarova PL, Graca J, Hanif UK, Müller C, Manhardt T, Salzmann M, Quasnichka H, Price SA, Ward DT, Gilbert T, Matchkov VV, Fenton RA, Herberger A, Hwong J, Santa Maria C, Tu CL, Kallay E, Valenti G, Chang W, Riccardi D. Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells. J Am Soc Nephrol. 2022 May 17:ASN.2021040585. doi: 10.1681/ASN.2021040585. Epub ahead of print. PMID: 35581010.

This work was supported by the European Commission Marie Curie Innovative Training Network Grant FP7-264663 “Multifaceted CaSR” (to D. Riccardi, S. Price, and E. Kallay), Austrian Science Fund Grant P-29948-B28 (to E. Kallay), Austrian Science Fund and Herzfelder’sche Familienstiftung Grant P-32840-B (to M. Schepelmann), “Intervento cofinanziato dal Fondo di Sviluppo e Coesione 2007-2013–APQ Ricerca Regione Puglia, Programma Regionale a Sostegno della Specializzazione Intelligente e della Sostenibilità Sociale ed Ambientale–FutureInResearch” CHVNKZ4 (to M. Ranieri), National Institutes of Health grants R01DK12165601 and R01DK122259, and Biomedical Laboratory Research and Development, VA Office of Research and Development grants I01BX005851 and 1IK6BX004835 (to W. Chang).

 
 
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