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Heat-labile Escherichia coli toxin enhances the induction of allergen-specific IgG antibodies in epicutaneous patch vaccination

C. R. Cabauatan1, R. Campana1, K. Niespodziana1, C. Reinisch2, U. Lundberg2, A. Meinke2, R. Henning3, A. Neubauer3 & R. Valenta1 1Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for...[more]

 

The Calcium-Sensing Receptor and the Reproductive System

Isabella Ellinger REVIEW ARTICLE Front. Physiol., 30 August 2016 [more]

 

AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer

Svoboda M, Meshcheryakova A, Heinze G, Jaritz M, Pils D, Castillo-Tong DC, Hager G, Thalhammer T, Jensen-Jarolim E, Birner P, Braicu I, Sehouli J, Lambrechts S, Vergote I, Mahner S, Zimmermann P, Zeillinger R and Mechtcheriakova...[more]

 

EAACI Molecular Allergology User's Guide

Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA,...[more]

 

IgE epitope proximity determines immune complex shape and effector cell activation capacity.

Anna Gieras PhD, Birgit Linhart PhD, Kenneth H. Roux PhD, Moumita Dutta PhD, Marat Khodoun PhD, Domen Zafred PhD, Clarissa R. Cabauatan PhD, Christian Lupinek MD, Milena Weber MSc, Margarete Focke-Tejkl PhD, Walter Keller PhD,...[more]

 

Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

Anastasia Meshcheryakova, Martin Svoboda, Ammar Tahir, Harald C. Köfeler, Alexander Triebl, Felicitas Mungenast, Georg Heinze, Christopher Gerner, Philip Zimmermann, Markus Jaritz, Diana Mechtcheriakova. (2016) Oncotarget. DOI:...[more]

 

“Frequent occurence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic recombinant Bet v 1 fragments”

J Allergy Clinical Immunol 2016; 137(2):601-609.e8[more]

 
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Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

Martin Schepelmann (group Enikö Kallay) and national and international colleagues and collaborators have just published a study in the Journal of the American Society of Nephrology (JASN), one of the highest ranked and most prestigious journals in the nephrology field.

The Calcium-Sensing Receptor (CaSR) is a protein which is best known for its role in maintaining mineral ion homeostasis in the blood. In this study, the role of this protein in blood vessels was investigated by characterizing a mouse in which the CaSR had been genetically deleted from vascular smooth muscle cells. They found that these mice suffer from a profound mineral ion imbalance, specifically hypercalcemia, hypercalciuria, and hyperphosphaturia. As kidney and parathyroid functions were normal, these results suggest a hitherto unknown mode how blood vessels contribute to mineral ion homeostasis control.

Schepelmann M, Ranieri M, Lopez-Fernandez I, Webberley TS, Brennan SC, Yarova PL, Graca J, Hanif UK, Müller C, Manhardt T, Salzmann M, Quasnichka H, Price SA, Ward DT, Gilbert T, Matchkov VV, Fenton RA, Herberger A, Hwong J, Santa Maria C, Tu CL, Kallay E, Valenti G, Chang W, Riccardi D. Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells. J Am Soc Nephrol. 2022 May 17:ASN.2021040585. doi: 10.1681/ASN.2021040585. Epub ahead of print. PMID: 35581010.

This work was supported by the European Commission Marie Curie Innovative Training Network Grant FP7-264663 “Multifaceted CaSR” (to D. Riccardi, S. Price, and E. Kallay), Austrian Science Fund Grant P-29948-B28 (to E. Kallay), Austrian Science Fund and Herzfelder’sche Familienstiftung Grant P-32840-B (to M. Schepelmann), “Intervento cofinanziato dal Fondo di Sviluppo e Coesione 2007-2013–APQ Ricerca Regione Puglia, Programma Regionale a Sostegno della Specializzazione Intelligente e della Sostenibilità Sociale ed Ambientale–FutureInResearch” CHVNKZ4 (to M. Ranieri), National Institutes of Health grants R01DK12165601 and R01DK122259, and Biomedical Laboratory Research and Development, VA Office of Research and Development grants I01BX005851 and 1IK6BX004835 (to W. Chang).

 
 
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