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Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations

Common variable immunodeficiency is the most common symptomatic primary immunodeficiency that is characterized by low levels of serum IgG, IgA and sometimes IgM. The patients suffer from recurrent infections of the upper and...[more]

 

Antibody shield protects against pollen allergy and rhinovirus infection

The fact that allergic inflammation and rhinovirus infection act synergistically in triggering airway inflammation gathered authors´ interest to develop a treatment that is effective for allergic as well as rhinovirus-induced...[more]

 

Generation of high affinity ICAM-1-specific nanobodies and evaluation of their suitability for allergy treatment

Ines Zettl, Tatiana Ivanova, Mohammed Zghaebi, Marina V. Rutovskaya, Isabella Ellinger, Oksana Goryainova, Jessica Kollárová, Sergio Villazala-Merino, Christian Lupinek, Christina Weichwald, Anja Drescher, Julia Eckl-Dorna,...[more]

 

Nothobranchius furzeri, the Turquoise Killifish: A Model of Age-Related Osteoporosis?

Maria Butylina, PhD-student in the group of Prof. Dr. Peter Pietschmann, published recently her research on Nothobranchius furzeri, the turquoise killifish, in Gerontology. [more]

 

Isolation of nanobodies with potential to reduce patients' IgE binding to the major birch pollen allergen, Bet v 1

Ines Zettl, Tatiana Ivanova, Maria R. Strobl, Christina Weichwald, Oksana Goryainova, Evgenia Khan, Marina V. Rutovskaya, Margarete Focke- Tejkl, Anja Drescher, Barbara Bohle, Sabine Flicker, Sergei V. Tillib Allergy 2022...[more]

 

Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

Martin Schepelmann (group Enikö Kallay) and national and international colleagues and collaborators have just published a study in the Journal of the American Society of Nephrology (JASN), one of the highest ranked and most...[more]

 

Vaccine based on folded RBD-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variants

The preclinical data for a vaccine developed at MedUni Vienna to protect against SARS-CoV-2 indicates that it is effective against all SARS-CoV-2 variants known to date, including omicron - even in those who have not yet built up...[more]

 
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Nothobranchius furzeri, the Turquoise Killifish: A Model of Age-Related Osteoporosis?

Maria Butylina, PhD-student in the group of Prof. Dr. Peter Pietschmann, published recently her research on Nothobranchius furzeri, the turquoise killifish, in Gerontology.

This study revealed that osteoblasts and mono- and multinucleated osteoclasts, but no osteocytes are present in the vertebral area of Nothobranchius furzeri. Furthermore, we detected age- and sex-related alterations of vertebral structural parameters and bone remodeling, which makes the turquoise killifish a promising novel model for the study of age-related musculoskeletal diseases. This work was part of Marias Master thesis project, which she performed also in the group of Peter Pietschmann in collaboration with the group of Prof. Oliver Pusch (Center of Anatomy and Cell Biology). Furthermore, this is her first publication as first author.

 

DOI: 10.1159/000524300

 
 
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