Senior Supervisor N094
Molecular mechanisms of oncogenesis in fusion-protein driven Leukemia. Exploitation of novel technologies for functional analysis of cancer mutations. Epigenetic and transcriptional control of gene expression. Analysis of proteome dynamics. Bioinformatic data integration. Translation of findings from basic research to clinical application.
We use a multidisciplinary approach to dissect molecular mechanisms that underlie cancer development.
Cancer is caused by dysfunction of factors that are required to regulate normal development. Recent genomic studies have shown that cancer-driving oncoproteins often arise from mutations in genes that encode transcription factors and epigenetic modulators.
We believe that oncogenic mechanisms oncogenic fusion proteins are hard-wired in specific networks of physical, genetic and epigenetic interactions with key effector proteins. Functional exploration of these networks will provide new insights into cellular processes that depend on critical effector proteins of oncoproteins.