Function:

Junior Supervisor N094

Research Interests:

Pediatric cancers, Epigenomics, Liquid biopsy, Single cell technologies, Tumor microenvironment, Bioinformatics

Research Focus:

The goal of our research group is to uncover the roles of epigenetic deregulation as an oncogenic mechanism, with a focus on fusion-driven pediatric sarcomas.

We study how fusion proteins rewire healthy cells for malignancy, with the perspective of exploiting this knowledge for improving pediatric sarcoma therapy.

We are applying state-of-the-art technologies that combine wet-lab and computational methods investigating:

• Non-genetic mechanisms of tumor formation orchestrated by oncogenic fusion proteins
• Contribution of the cellular state of the corresponding cell of origin to cancer development
• Epigenetic heterogeneity as source of cellular plasticity providing novel therapeutic paradigms
• Non-genetic based biomarkers for patient stratification and real time disease monitoring