Function:

Junior Supervisor N094

Research Interests:

Chemical Biology, Targeted Protein Degradation, Leukemia, Transcription Regularion, Functional Genomics, Chemical Proteomics, Drug-target identification, Drug Mechanism of action studies, Cancer Drug Resistance, Molecular Glue Degraders, PROTACs

Research Focus:

Thematically, research in my lab is focused on the interface of cancer, chemical biology and gene control. We aim to innovate novel (pharmacologic) strategies that allow us to probe, understand and eventually target aberrant transcriptional circuits in cancer.

Our science is thus unapologetically translational, but we nevertheless aim to ask scientific questions that are fundamental in nature and allow us to develop a better understanding of gene control and the ubiquitin-proteasome system.

Our research strategy is inspired and driven by high-throughput and unbiased technologies such as quantitative proteomics, (nascent) transcriptomics and functional genomics.

Integrative use of these technologies enables us to understand the mechanism of action of proteins, protein complexes or small molecules on a holistic level.

In almost all cases, we are however not satisfied by merely charting the global picture, but rather use this multi-omics approaches to establish hypotheses that are followed up on a mechanistic level.

Currently, the main focus of the group is to push the limits of targeted protein degradation, and -in the wider sense- proximity-inducing drugs, as a novel paradigm in therapeutic discovery.