Work address
Medical University of Vienna
Department of Internal Medicine II/Cardiology
Waehringer Guertel 18-20
1090 Vienna, Austria
Phone: +43 (0)1 40400 4614
E-Mail: irene.lang@meduniwien.ac.at
Know-how and research interests
My group focuses on the pathogenesis of vascular occlusion, examining mechanisms of loss of patency in atherosclerotic vascular disease and venous thromboembolism. Our projects target the understanding of the vascular barrier, separating “in” from “out”. Particular emphasis is on the conundrum of acute vascular syndromes and the plaque rupture hypothesis. Another focus is on venous occlusive disease by means of a mouse model of vena cava ligation resembling human deep vein thrombosis.
Current research interests are
Research topic (general title)
Techniques and infrastructure of the research group
Isolation, characterization and referencing of human vascular tissues by micro computed tomography, FACS, angiogenesis assays (BrdU assay, sprouting assay), in situ diagnostic and analytical tools (in situ hybridization, TissueFacs, immunohistochemistry, RealTime-PCR, ELISA, Western Blot), various constitutive and conditional gene deletion mouse models.
5 selected publications