Univ. Prof. Dr. Irene Lang
Work address
Medical University of Vienna
Department of Internal Medicine II/Cardiology
Waehringer Guertel 18-20
1090 Vienna, Austria
Phone: +43 (0)1 40400 4614
E-Mail: irene.lang@meduniwien.ac.at
Know-how and research interests
My group focuses on the pathogenesis of vascular occlusion, examining mechanisms of loss of patency in atherosclerotic vascular disease and venous thromboembolism. Our projects target the understanding of the vascular barrier, separating “in” from “out”. Particular emphasis is on the conundrum of acute vascular syndromes and the plaque rupture hypothesis. Another focus is on venous occlusive disease by means of a mouse model of vena cava ligation resembling human deep vein thrombosis.
Current research interests are
- Adaptive immune cells and venous thrombus resolution
- The role of angiogenesis in vascular occlusion
- Neutrophil extracellular traps in acute vascular syndromes
- The biology of thrombus scaffolds
Research topic (general title)
Mechanisms maintaining vascular patency
Techniques and infrastructure of the research group
Isolation, characterization and referencing of human vascular tissues by micro computed tomography, FACS, angiogenesis assays (BrdU assay, sprouting assay), in situ diagnostic and analytical tools (in situ hybridization, TissueFacs, immunohistochemistry, RealTime-PCR, ELISA, Western Blot), various constitutive and conditional gene deletion mouse models.
5 selected publications
- Platelet endothelial cell adhesion molecule 1 (PECAM-1) deficiency misguides venous thrombus resolution. Blood 2013 in press
- Surgical specimens, hemodynamics and long-term outcomes after pulmonary endarterectomy. doi: 10.1136/thoraxjnl-2013-203746
- Diastolic pulmonary vascular pressure gradient: a predictor of prognosis in "out-of-proportion" pulmonary hypertension. Chest 2013;143:758-66
- Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J 2012;40:874-80.
- Chronic thromboembolic pulmonary hypertension--not so rare after all. N Engl J Med 2004;350:2236-8.