Medical University of Vienna
Department of Internal Medicine II, Division of Cardiology
Waehringer Guertel 18-20
1090 Vienna, Austria
Phone: +43 (0)1 40400 4614
Know-how and research interests
Our lab consists of three main working parts:
- animal experiments including a) testing of medical devices and new cardiac implants, such as coronary stents, balloons, occlusion of left atrial appendage, PFO or ASD; b) elaboration of new animal models of human diseases, such as cardiac hypertrophy or chronic thrombotic occlusion of a coronary artery; c) different myocardial ischemia, reperfusion and infarction models
- routine microscopic histology and analysis and immunohistochemistry
- molecular biology work including isolation of cells, cell culture, cell seeding technologies, transfection of cells, rtPCR, gene expression analyses.
Research topic (general title)
Myocardial ischemia, regeneration and translational research
Techniques and infrastructure of the research group
Our lab consists of one Post-doc lab leader (EU Project financing), medical technician assistant (20h/week, in education and writing Master-Thesis), a PhD student (FWF-financing for 3 years) and another Master-Thesis student, medical students writing experimental diploma work and SciMed physicians doing scientific work. According to the three main parts of our group, we do large animal experiments in the field of invasive cardiology, routine microscopic histology, immunohistochemistry and molecular biology work. Our lab is equipped with cell culture, light microscope, stereomicroscope (from 2014), fluorescent microscope, analytic software with computers. We have excellent cooperation with the TU regarding imaging modalities (eg. scanning electronmicroscopy) and with CD Labor with additional molecular lab facilities, such as rtPCR.
5 selected publications
- Gyöngyösi M, Dib N. Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease. Nature Reviews Cardiology 2011;8:393-404
- Gyöngyösi M, et al. Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study. Nature Clin Pract Cardiovasc Med 2009;6:70-81.
- Gyöngyösi M, et al. Serial non-invasive in vivo positron emmission tomographyc (PET) tracking of percutaneously intramyocardially injected autologous porcine mesenchymal stem cells modified for transgene reporter gene expression Circulation: Cardiovasc Imaging 2008:1:94-103.
- Gyöngyösi M, et al. NOGA-Guided Analysis Of Regional Myocardial Perfusion Abnormalities Treated With Intramyocardial Injections Of Plasmid Encoding VEGF A-165 In Patients With Chronic Myocardial Ischemia. Subanalysis Of The EUROINJECT-ONE Multicenter Double-Blind Randomized Study. Circulation 2005 112[suppl I]:I-157–I-165.
- Gyöngyösi M, et al. On-line Myocardial Viability Assessment in the Catheterization Laboratory via NOGA Electroanatomic Mapping. Quantitative Comparison With Thallium-201 Uptake. Circulation 2001;104.1005-1011.