Medical University of Vienna
Department of Internal Medicine II
Waehringer Guertel 18-20
1090 Vienna, Austria
Phone: +43 (0)1 40400 4670
Know-how and research interests
- Interrelationship of atherosclerosis, chronic inflammation and insulin resistance
Increasing evidence suggests an interrelationship of atherosclerosis, chronic inflammation and insulin resistance. Thus, one of our research interests is the investigation of novel inflammatory proteins in patients with high risk of cardiovascular disease such as morbidly obese patients, hypopituitary patients, or patients with various types of diabetes.
- Endothelial progenitor cells in diabetes
Endothelial progenitor cells (EPC) are believed to have a crucial role in acute and chronic atherosclerosis. We are currently enumerating EPC in patients with different stages of insulin resistance, type 1 diabetes (children & adults), type 2 diabetes, and gestational diabetes and LADA, all with and without macro- and microvascular complications.
- Peripheral arterial occlusive disease (+/- insulin resistance or +/- type 2 diabetes)
Peripheral arterial occlusive disease (PAOD) differs in patients with diabetes from all others. Thus, the differential expression of inflammatory proteins in patients with PAOD alone, with pre-diabetes (insulin resistance syndrome) or overt type 2 diabetes is of key interest.
- Platelet activation & involvement in insulin resistance, inflammation, atherosclerosis
Platelet activation is believed to have a key role in acute and chronic atherosclerosis. We are currently investigating up- and downregulation of platelet surface activation-linked molecules in patients with different stages of insulin resistance and/or overt type 2 diabetes mellitus.
Research topic (general title)
Interrelationship of atherosclerosis, chronic inflammation and insulin resistance
Techniques and infrastructure of the research group
- Isolation, characterization and cultivation of human primary cells
- Immunology Techniques such as Flow Cytometry, ELISA and Immunohistochemistry
- Molecular Biology Technqiues such as PCR and RT-PCR
- Diverse Patient Cohorts such as
- PAD +/- NDM/PDM/DM
- T1DM Children and adolescents
- MO pre /post Surgery
- T1DM without atherosclerosis
- T2DM without atherosclerosis
- LADA without atherosclerosis
- T1DM with Retinopathy and/or Albuminuria
- T2DM with Retinopathy and/or Albuminuria
- LADA with Retinopathy and/or Albuminuria
5 selected publications
- Hörtenhuber T, Rami-Mehar B, Satler M, Nagl K, Höbaus C, Höllerl F, Koppensteiner R, Schernthaner G, Schober E, Schernthaner GH. Endothelial Progenitor Cells Are Related to Glycemic Control in Children With Type 1 Diabetes Mellitus Over Time. Diabetes Care. 2013
- Schlager O, Hammer A, Willfort-Ehringer A, Fritsch M, Rami-Merhar B, Schober E, Nagl K, Giurgea A, Margeta C, Zehetmayer S, Schernthaner GH, Koppensteiner R, Gschwandtner ME. Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus. Diabetologia. 2012 Jun;55(6):1633-40.
- Batinic K, Höbaus C, Grujicic M, Steffan A, Jelic F, Lorant D, Hörtenhuber T, Hoellerl F, Brix JM, Schernthaner G, Koppensteiner R, Schernthaner GH. YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes. Atherosclerosis. 2012 Jun;222(2):557-63.
- Lorant D, Grujicic M, Hoebaus C, Brix J-M, Hoellerl F, Schernthaner G, Koppensteiner R, Schernthaner G-H. Fetuin-A levels are increased in patients with type 2 diabetes and peripheral arterial disease. Diabetes Care 2010
- Ay L, Kopp HP, Brix JM, Ay C, Quehenberger P, Schernthaner GH, Pabinger I, Schernthaner G. Thrombin generation in morbid obesity: significant reduction after weight loss. J Thromb Haemost. 2010