MedUni Wien    Intranet    MedUni Wien - Shop    Universitätsbibliothek    Universitätsklinikum AKH Wien  
 
npn.gif
 
 
Hauptnavigation
  • Home
  • Allgemeine Informationen
  • Diagnostik
  • Forschung
  • Lehre
 
Abteilung für Neuropathologie und Neurochemie, Subeinheit der Universitätsklinik für Neurologie / Allgemeine Informationen / MitarbeiterInnen / Mag. Inga Koneczny, DPhil
 
Subnavigation
  • Aufgaben
  • MitarbeiterInnen
    • Univ.Prof. Dr. Johannes Hainfellner
    • Dr. Ellen Gelpi-Mantius
    • Ao.Univ.Prof. Dr. Christine Haberler
    • Assoc.Prof. Dr. Romana Höftberger
    • Mag. Inga Koneczny, DPhil
    • Dr. Günther Regelsberger
    • Dr. Thomas Roetzer
    • Ao.Univ.Prof. Dr. Thomas Ströbel
    • Assoc.Prof.Priv.Doz. Dr. Till Voigtländer
    • Dr. Adelheid Wöhrer
    • pens.Univ.Prof. Dr. Herbert Budka
  • Kontakt
  • Rechtliche Hinweise


Inhaltsbereich

Inga Koneczny, DPhil

Academic curriculum vitae

Personal data

Name:              Inga Koneczny, DPhil

ORCID ID:       0000-0002-0567-021X

Address:           Medical University of Vienna

Clinical Institute of Neurology

Waehringer Guertel 18-20

1090 Vienna, Austria

Websites:     https://www.meduniwien.ac.at/web/index.php?id=688&res_id=392&name=Inga_Koneczny

                    https://www.researchgate.net/profile/Inga_Koneczny

                    https://www.linkedin.com/in/inga-koneczny-6575a1a8/

research-careers.org

Main areas of research: Myasthenia gravis, Neuroimmunology, IgG4 Autoimmunity

Contributions to science: Inga Koneczny made groundbreaking contributions to the field of Myasthenia gravis research and IgG4 autoimmunity. During her DPhil studies at the University of Oxford with Prof. Angela Vincent, FRS FRCPath, she was the first to unravel the pathogenic mechanisms of MuSK autoantibodies as a functional block of binding between MuSK and Lrp4, and demonstrated their pathogenicity in vitro. The work was published open-access at PloS One and reached the top 10% of most cited articles in 2017. In her postdoctoral work with Prof. Marc De Baets and Drs Pilar-Martinez-Martinez and Mario Losen, she was the first to discover that MuSK autoantibodies, which belong to the rare IgG4 subclass, are bispecific in vivo in the patient serum, and that bispecific autoantibodies and Fab fragments are pathogenic in vitro. In further projects she investigated the involvement of the thymus in Lrp4 MG, and the impact of long-term immunosuppression on IgG subclass distribution. She also contributed to reviews and wrote a book chapter for the Encyclopedia of Immunobiology. She was awarded three  prestigious stipends from the Austrian science fund and the Austrian academy of sciences, two travel grants, one prize for the best conference poster and was invited speaker at several conferences.

Academic career

Sept 2018-

Project leader

Clinical Institute of Neurology

Vienna, Austria

Nov 2016 – August 2018

Post-Doctoral Position

Clinical Institute of Neurology

Vienna, Austria

Oct 2014 – Oct 2016

Post-Doctoral Position

Maastricht University, MHeNS School for Mental Health and Neuroscience

Maastricht, Netherlands

Mar 2014 – Sep 2014

Post-Doctoral Position

Yale University, Department of Neurology

New Haven, United States

Education

 

Oct 2010 – Feb 2014

University of Oxford

DPhil, Clinical Neurosciences, United Kingdom

Oct 2003 – Oct 2009

University of Vienna

Magister, Molecular Biology, Austria

Academic recognition, prizes, awards

2019

Invited speaker at the 14th Dresden Symposium on Autoantibodies

2019

Young Investigator Award for best oral presentation at the 5th International Congress on Controversies in Rheumatology and Autoimmunity in Florence

2019

Invited speaker at the 5th International Congress on Controversies in Rheumatology and Autoimmunity in Florence

2018

Selected speaker at the Autoimmunity Congress in Lisbon

2017

Travel grant to the 13th International Conference on Myasthenia gravis and related Diseases, New York

2013

Award: Best Poster at Myasthenia gravis conference Paris

2013

Eva Dresel conference travel award

2013

Selected speaker at the Muscle Study Group (MSG) Annual Meeting, Oxford.

2001

Heinrich Aldegrever Award for excellent performance at school

Review activities and memberships in academic organization

Memberships in academic organizations

Dutch Society for Immunology

New York Academy of Sciences

Austrian Neuroscience Association

Österreichische Gesellschaft für Allergologie und Immunologie

Invited open peer review

Phillips, W.D. and A. Vincent, Pathogenesis of myasthenia gravis: update on disease types, models, and mechanisms. F1000Res, 2016. 5.

Peer review

Reviewing for PlosOne

Most important research projects funded in
the past

2018

Hertha Firnberg project grant by the Austrian Science Fund (FWF) “Biological Markers in Myasthenia gravis” project number T996-B-30.

2014

Scholarship: Erwin-Schrödinger Postdoctoral Fellowship by the Austrian Science Fund (FWF), “What are the pathogenic mechanisms of MuSK-Myasthenia gravis?”- DPhil project at the University of Oxford, supervision by Angela Vincent, FRS FRCPath. Project number J 3545-B13.

2011

Scholarship: Doc fFORTE fellowship of the Austrian Academy of Sciences (ÖADW) “What B cells are pathogenic in MuSK-Myasthenia gravis?” – Post-doctoral research project at Yale University/ Maastricht University and the Medical University of Vienna, mentored by Dr. Kevin O’Connor, Prof. Marc de Baets and Prof. Romana Höftberger

 

Public outreach / Presss

2019

Articles relating to our discovery of Lrp4 Myasthenia gravis in a patient with a new strain of Leptospirosis interrogans:

https://www.myscience.at/news/2019/expertinnen_der_meduni_wien_und_des_akh_wien_identifizieren_
bisher_unbekannten_bakterienstamm-2019-meduniwien

 

https://cluster.meduniwien.ac.at/mnc/news/single-view/?tx_ttnews%5Btt_
news%5D=3904&cHash=abed0f57c3ccfcc227167f93214fe149

 

https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/2019/
news-im-mai-2019/experts-from-meduni-vienna-and-vienna-
general-hospital-identify-previously-unknown-bacterial-strain/

 

https://www.credoweb.at/publication/107187/expertinnen-der-meduni-
wien-und-des-akh-wien-identifizieren-bisher-unbekannten-bakterienstamm

 

https://www.lisavienna.at/news/meduni-wien-expertinnen-der-meduni-
wien-und-des-akh-wien-identifizieren-bisher-unbekannten-bakterie-1/

 

2019

Bezirkszeitung Wien, meinbezirk.at

https://www.meinbezirk.at/wien/c-wirtschaft/ein-koerper-der-
zum-feind-wird_a3148893?fbclid=

IwAR1HPGLQimJ5oplYjHyip8228EQGoKOr7SMiw71LIW2n1B_
MwGNq7Zr4jWU

2018

MedUnique magazine and MUW website

“Inga Koneczny awarded "Hertha Firnberg" scholarship by
the FWF”

https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/2018/news-im-juli-2018/inga-koneczny-awarded-hertha-
firnberg-scholarship-by-the-fwf/

 

Publication list

List of all peer-reviewed published or accepted scholarly publications in the last 5 years

Year

Original research

2019

Tomschik, M.; Koneczny, I.; Schotta, A.M.; Scharer, S.; Smajlhodzic, M.; Rosenegger, P.F.; Bluthner, M.; Hoftberger, R.; Zimprich, F.; Stanek, G., et al. Severe Myasthenic Manifestation of Leptospirosis Associated with New Sequence Type of Leptospira interrogans. Emerging infectious diseases 2019, 25, 968-971, doi:10.3201/eid2505.181591.

2018

Koneczny I, Rennspiess D, Marcuse F, Hamid MA, Damas M, Maessen J, Van Schil P, Saxena A, Zisimopoulou P, Lazaridis K, Woodhall M, Karagiorgou K, Tzartos J, Tzartos S, De Baets MH, Molenaar PC, Marx A, Hausen AZ, Losen M, Martinez-Martinez P. “Characterization of the thymus in Lrp4 myasthenia gravis: Four cases.” Autoimmun Rev. 2018 Nov 8. pii: S1568-9972(18)30260-X. doi: 10.1016/j.autrev.2018.07.011.

2017

 

Koneczny, I., J. A. Stevens, A. De Rosa, S. Huda, M. G. Huijbers, A. Saxena, M. Maestri, K. Lazaridis, P. Zisimopoulou, S. Tzartos, J. Verschuuren, S. M. van der Maarel, P. van Damme, M. H. De Baets, P. C. Molenaar, A. Vincent, R. Ricciardi, P. Martinez-Martinez and M. Losen (2017). "IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients." J Autoimmun 77: 104-115.

Saxena, A., Stevens, J., Cetin, H., Koneczny, I., Webster, R., Lazaridis, K., Tzartos, S., Vrolix, K., Nogales-Gadea, G., Machiels, B., Molenaar, P.C., Damoiseaux, J., De Baets, M.H., Simon-Keller, K., Marx, A., Vincent, A., Losen, M., and Martinez-Martinez, P. (2017). Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient. Sci Rep 7, 14426.

Rolf, L., A. H. Muris, A. Mathias, R. Du Pasquier, I. Koneczny, G. Disanto, J. Kuhle, S. Ramagopalan, J. Damoiseaux, J. Smolders and R. Hupperts (2017). "Exploring the effect of vitamin D3 supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis." Mult Scler: 1352458517722646.

Saxena, A., Stevens, J., Cetin, H., Koneczny, I., Webster, R., Lazaridis, K., Tzartos, S., Vrolix, K., Nogales-Gadea, G., Machiels, B., Molenaar, P.C., Damoiseaux, J., De Baets, M.H., Simon-Keller, K., Marx, A., Vincent, A., Losen, M., and Martinez-Martinez, P. (2017). Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient. Sci Rep 7, 14426.

2015

Koneczny, I., A. Schulenburg, X. Hudec, M. Knofler, K. Holzmann, G. Piazza, R. Reynolds, P. Valent and B. Marian (2014). "Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells." Mol Carcinog 54(9): 789-799.

2014

Huda, S., I. Koneczny, L. Jacobsen, D. Beeson and A. Vincent (2014). "SERONEGATIVE MYASTHENIA GRAVIS-CLINICAL/SEROLOGICAL ASPECTS." Journal of Neurology, Neurosurgery & Psychiatry 85(10): e4-e4.

2013*

Koneczny, I., J. Cossins, P. Waters, D. Beeson and A. Vincent (2013). "MuSK Myasthenia Gravis IgG4 Disrupts the Interaction of LRP4 with MuSK but Both IgG4 and IgG1-3 Can Disperse Preformed Agrin-Independent AChR Clusters." PLoS One 8(11): e80695.

*Top 10% of most cited articles of PloS One in 2017

2011

Rohrl, C., U. Kaindl, I. Koneczny, X. Hudec, D. M. Baron, J. S. Konig and B. Marian (2011). "Peroxisome-proliferator-activated receptors gamma and beta/delta mediate vascular endothelial growth factor production in colorectal tumor cells." J Cancer Res Clin Oncol 137(1): 29-39.

Year

Reviews

2019

Koneczny, I.; Herbst, R. Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture. Cells 2019, 8, doi:10.3390/cells8070671.

2018

 

Ricken G, Schwaiger C, De Simoni D, Pichler V, Lang J, Glatter S, Macher S, Rommer PS, Scholze P, Kubista H, Koneczny I, Höftberger R., “Detection Methods for Autoantibodies in Suspected Autoimmune Encephalitis.”Front Neurol. 2018 Oct 10;9:841. doi: 10.3389/fneur.2018.00841. eCollection 2018.

Vincent A, Huda S, Cao M, Cetin H, Koneczny I, Rodriguez-Cruz P, Jacobson L, Viegas S, Jacob S, Woodhall M, Nagaishi A, Maniaol A, Damato V, Leite MI, Cossins J, Webster R, Palace J, Beeson D. “Serological and experimental studies in different forms of myasthenia gravis.” Ann N Y Acad Sci. 2018 Feb;1413(1):143-153. doi: 10.1111/nyas.13592. Epub 2018 Jan 29. Review.

Koneczny, I., “A new classification system for IgG4 autoantibodies”. Front Immunol (Autoantibodies special issue).

2014

Cossins, J., K. Belaya, K. Zoltowska, I. Koneczny, S. Maxwell, L. Jacobson, M. I. Leite, P. Waters, A. Vincent and D. Beeson (2012). "The search for new antigenic targets in myasthenia gravis." Annals of the New York Academy of Sciences 1275(1): 123-128.

 

Koneczny, I., J. Cossins and A. Vincent (2014). "The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis." J Anat 224(1): 29-35.

2012

 

Vincent, A., P. Waters, M. I. Leite, L. Jacobson, I. Koneczny, J. Cossins and D. Beeson (2012). "Antibodies identified by cell-based assays in myasthenia gravis and associated diseases." Ann N Y Acad Sci 1274: 92-98.

Research chapters in collective volumes

2016

Koneczny I, Martinez-Martinez P, de Baets, M (2016). Myasthenia gravis. Encyclopedia of Immunobiology. M. J. H. Ratcliffe, Oxford: Academic Press. 5: 168-179.

 

 

 

Conference proceedings

2019

Koneczny, I, Update on IgG4 autoimmune diseases

Dresden, 14th Dresden Symposium on Autoantibodies, 10-13 Sept 2019

*Invited speaker

 

2019

Koneczny, I, A new classification system for IgG4 autoantibodies

Florence, Italy, 5th International Congress on Controversies in Rheumatology and Autoimmunity, 14-16 March 2019

*Selected speaker, Young Investigator Award

2018

Inga Koneczny, Jo A.A. Stevens, Anna De Rosa, Saif Huda, Maartje G. Huijbers, Abhishek Saxena, Michelangelo Maestri, Konstantinos Lazaridis, Paraskevi Zisimopoulou, Socrates Tzartos, Jan Verschuuren, Silvère M. van der Maarel, Philip van Damme, Marc H. De Baets, Peter C. Molenaar, Angela Vincent, Roberta Ricciardi, Pilar Martinez-Martinez, Mario Losen: IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients

Lisbon, 11th International Congress on Autoimmunity, 16-20 May 2018

*Selected speaker

2017*

Inga Koneczny, Jo A.A. Stevens, Anna De Rosa, Saif Huda, Maartje G. Huijbers, Abhishek Saxena, Michelangelo Maestri, Konstantinos Lazaridis, Paraskevi Zisimopoulou, Socrates Tzartos, Jan Verschuuren, Silvère M. van der Maarel, Philip van Damme, Marc H. De Baets, Peter C. Molenaar, Angela Vincent, Roberta Ricciardi, Pilar Martinez-Martinez, Mario Losen: IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients New York Academy of Sciences 2017 - 13th International Conference on Myasthenia Gravis and Related Disorders; 05/2017

*Award of a travel grant

2015

Koneczny, I., A. De Rosa, M. Maestri, J. verschuuren, M. G. Huijbers, P. Martinez-Martinez, M. De Baets, R. Riccardi and M. Losen (2015). Fab-arm exchange as a novel mechanism in myasthenia gravis with autoantibodies to muscle-specific kinase. 4th European Congress of Immunology (ECI), Vienna.

2014

Huda, S., I. Koneczny, L. Jacobsen, D. Beeson and A. Vincent "P45 Seronegative myasthenia gravis”2013; clinical and serological features." Neuromuscular Disorders 24: S19.

2013*

Koneczny I, Cossins J, M. Leite, B. Lang, Beeson D and V. A (2013). POTENTIAL MECHANISMS IN MUSK-MYASTHENIA GRAVIS. Muscle Study Group (MSG) Annual Meeting, Oxford.

*Invited Speaker

2013*

Koneczny, I., J. Cossins, M. Leite, B. Lang, D. Beeson and A. Vincent (2013). Potential mechanisms in MUSK-­Myasthenia Gravis. Myasthenia 2013, Paris.

*Award for best poster

*Eva Dresel conference travel award

 

 
Drucken
 

Schnellinfo

 
-- Einsendeformulare
-- CLINS
-- MitarbeiterInnen
-- Kontakt
-- ÖRPE - Treffen „Angehörige für Angehörige“
 
 

Featured

 
© MedUni Wien  | 
 Impressum | Nutzungsbedingungen | Datenschutzerklärung | Barrierefreiheit | Kontakt