Furthermore, our lab investigates how stem cells control their motility and the intertwined parameters of cell cycle, size and survival. We explore the molecular players and the signalling networks which govern these processes, and if or how these differ across stem cell types. In this context but not exclusively restricted to stem cell research, we have an already long lasting interest in the TSC/mTOR pathway (see e.g. Soucek, Yeung, Hengstschläger: Inactivation of cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proceedings of the National Academy of Science 95, 15653; Linke, Pham, Katholnig, Schnöller, Miller, Demel, Schütz, Rosner, Kovacic, Sukhbaatar, Niederreiter, Blüml, Kuess, Sexl, Müller, Mikula, Weckwerth, Haschemi, Susani, Hengstschläger, Gambello, Weichhart: Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nature Immunology 18, 293)
Another key aim is to understand how stem cells communicate with other cells ("the language of stem cells") and how this affects stem cell-related processes such as stem cell tumourigenesis. This includes the identification and characterisation of stem cell-derived paracrine stimuli (Figs. 2 and 3).