Professor of Pathophysiology and Allergy Research

Division of Cellular Allergology
Institute of Pathophysiology and Allergy Research
Center for Pathophysiology, Infectiology and Immunology
Währinger Gürtel 18-20, 1090 Vienna, Austria

Phone: +43 (0)1 40400 - 51140
FAX: +43 (0)1 40400 - 61880

E-mail: barbara.bohle@meduniwien.ac.at
Homepage:http://www.meduniwien.ac.at/ipp/allergyresearch

Research Interests
We have a long standing interest in elucidating the immune mechanisms underlying the induction, maintenance and successful treatment of IgE-mediated hypersensitivity reactions and in developing novel concepts for an efficient and safe allergen-specific immunotherapy of these diseases.
Our long-term research interest is to understand the immune mechanisms that regulate the development and maintenance of allergy, in particular at the T cell level. One major goal is to understand and influence the interaction of T lymphocytes and antigen-presenting cells. In parallel, ongoing research in my laboratory focuses on the development of vaccines that modulate the disease-eliciting immune response and thereby cure allergic disorders.

Allergen-specific immune responses in disease and cure

Abstract

To understand the immune mechanisms of IgE-mediated hypersensitivity we characterize allergen-specific T cells isolated from allergic and non-allergic individuals regarding their phenotype, expression of surface molecules, cytokine responses, epitope recognition and T cell receptor usage.
Moreover, we characterize the specificity and effector functions of different allergen-specific antibody subclasses.
Our methodological approach involves various immunological methods, flow cytometry, tissue culture techniques as well as recombinant DNA technology.

Selected Publications

Schulten, V., B. Nagl, E. Scala, M. L. Bernardi, A. Mari, M. A. Ciardiello, I. Lauer, S.Scheurer, P. Briza, A. Jürets, F. Ferreira, B. Jahn-Schmid, G. F. Fischer, and B. Bohle (2011). Pru p 3, the non-specific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. Allergy, in press

Geroldinger-Simic, M., T. Zelniker, W. Aberer, C. Ebner, C. Egger, A. Greiderer, N. Prem, J. Lidholm, B.K. Ballmer-Weber, S. Vieths, and B. Bohle (2011). Birch pollen-related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol. in press 10.1016/j.jaci.2010.10.027