Professor of Internal Medicine
Medical University of Vienna
Department of Medicine I
Währinger Gürtel 18-20
1090 Vienna, Austria
Phone: +43 (0)1 40400 - 44400
Cytomegalovirus structure and B-cell immunity in relation to hemato-oncologic diseases and immunosuppression.
Molecular mechanisms of Cytomegalovirus-specific immunity
The focus of our research is on the interaction between Cytomegalovirus and the human immune system. This human herpesvirus employs more than 100 different mechanisms that allow the virus to modulate and subvert the host's immune response. The immune system adapts to its opponent.
The equilibrium of forces is tipped by the occurrence of an immunodeficiency in the course of an organ-transplantation or HIV infection.
We aim at elucidating critical immunological and biological mechanisms, that may tip the balance in favour of the humans.
We evaluate these mechanisms in close collaboration with the Division of Hematology and Hemostaseology, the Center for Optimized Structural Studies, COSS of the Max F. Perutz Laboratories, and the Institute of Immunology with special focus on the role of CMV infection the evolution of chronic lymphocytic leukemia (Steininger et al. Blood 2012).
In addition, we study gastrointestinal infections for the identification of effective preventive and therapeutic strategies. These projects are done in close collaboration with several Centers for Gastrointestinal Medicine.
This focus includes particularly the optimization of H. pylori eradication therapies and prevention of abdominal infections complicating implantation of endoprostheses.
- Marie-Theres Kastner MTA
- Franz Rieder PhD student
- Martina Schneider PhD student
- Julia Biebl Masterstudent
- Kathrin Kohler Diploma student
- Jakob Thannesberger Diploma student