Professor of Pathophysiology and Allergy Research
Department of Pathophysiology and Allergy Research
Center of Pathophysiology, Infectiology and Immunology
Medical University of Vienna
Währinger Gürtel 18-20, 1090 Vienna, Austria
Phone: +43 (0)1 40400 - 28600
FAX: +43 (0)1 40400 - 61880
Specific areas of interest include B-cell biology and assemble / functionality of ectopic lymphoid structures at sites of chronic inflammation; basic and translational research in tumor immunology; large-scale characterization of immunological imprint of human tumors; innovative imaging; multigene approach for patient stratification and risk assessment; novel applications of bioinformatics and biostatistics.
Molecular mechanisms at interface of B-cell immunity, inflammation and cancer
The main research focus of our Molecular Systems Biology & Pathophysiology group is characterization of cellular checkpoints, which redirect the physiologically balanced system to the pathological situations leading to development and progression of multifactorial diseases such aberrant immunity, chronic inflammation and cancer. Additional focus is given to establishment of gene-/pathway-/disease-relevant multigene signatures for prediction of biological outcomes under diseased conditions as strategy towards patient-orientated medical care.
In this respect, two research areas are of particular interest: activation-induced cytidine deaminase (AID)-associated biological events and sphingolipid-related cellular machinery. The following listed key words reflect the basic scientific questions and translational aspects of or research: immune cell activation, migration; interface between innate and adaptive immunity; B-cell survival vs apoptosis; AID&S1P/Ceramide; GC-like ectopic follicle formation/ mechanisms; genetics and epigenetics; DNA aberrations; cell plasticity and pluripotency; immunological imprint; prognostic effect/models.
The experimental approaches to address our research questions include real-time PCR-based multigene approach for gene expression profiling of patient material and diseased-relevant cellular models; bioinformatics approaches to delineate disease-relevant pathways/targets; statistical modelling; automated microscopy-based imaging platform for qualitative and quantitative analyses of large-scale diseased tissue specimens; live-cell imaging; flow cytometry; gain-of-/loss-of-function approaches via transient transfection in cellular systems; cell-based epithelial to mesenchymal transition model.
More information about the various research projects and our Team can be found <here>