Professor of Vascular Biology and Thrombosis Research
Department of Vascular Biology and Thrombosis Research
Center for Physiology and Pharmacology
Lazarettgasse 19, 1090 Vienna, Austria
Phone: +43 (0)1 40160 - 31151
FAX: +43 (0)1 40160 - 931150
NK cell differentiation and function, transcriptional regulation of differentiation, signal transduction, anti-tumor functions of NK cells.
Differentiation and anti-tumor functions of natural killer cells
We are a molecular cell biology laboratory studying different aspects of molecular immunology and vascular biology.
One project deals with the differentiation of human natural killer (NK) cells from hematopoietic stem cells and their anti-tumor reactivity.
We use an ex vivo system to generate NK cells from cord blood CD34+ stem cells to study the regulation of NK cell differentiation.
Genes/proteins specifically upregulated during differentiation are investigated. We are especially interested to better understand the control of differentiation by transcription factors and to achieve functional maturation in vitro.
A translational goal of this project is further to develop methods to generate NK subpopulations with increased anti-tumor reactivity.
A second project is focused on the differentiation of human endothelial cells and the regulation of vessel formation (see PhD programs Molecular Signal Transduction and Vascular Biology).
More information about the various research projects can be found at our homepage http://homepage.univie.ac.at/erhard.hofer/
Lehmann, D., Spanholtz, J., Sturtzel, C., Tordoir, M., Schlechta, B., Groenewegen, D. and Hofer, E. (2013). IL-12 directs further maturation of ex vivo differentiated NK cells with imnproved therapeutic potential. PlosOne, in press.
Lehmann, D., Spanholtz, J., Osl, M., Tordoir, M., Lipnik, K., Bilban, M., Schlechta, B., Dolstra, H. and Hofer, E. (2012). Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells. Stem Cells Dev 21, 2926-2938.
Testori, J., Schweighofer, B., Helfrich, I., Nasarre, P., Sturtzel, C., Bilban, M., Augustin, H. and Hofer, E. (2011). The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells. Blood 117, 2735-2744.