Professor of Immunology
Division of Clinical and Experimental Immunology
Institute of Immunology
Center for Pathophysiology, Infectiology and Immunology
Lazarettgasse 19, 1090 Vienna, Austria
Phone: +43 (0)1 40160 - 33271
FAX: +43 (0)1 40160 - 933271
Determinants of local immunity, molecular mechanisms of immunomodulation, immunometabolism.
Mechanisms of Immunomodulation
Central to my research efforts is to learn more about physiological and pathophysiological conditions of immune reactivity in different clinical states and in relation to the involved compartments of the body.
A longstanding interest of my research group concentrates on the issue of naturally occurring ways of immunomodulation as particularly operating in local immunity and on clinical conditions in consequence of inappropriate immune reactivity as observed after transplantation or in autoimmune diseases.
Identification of immunological deregulation as early as possibly and the understanding of the ongoing processes are pivotal for early diagnosis and the development as well as implementation of purposeful interference strategies.
More information about the various research projects can be found <here>
„State of the art“ basic molecular and cellular biology techniques, biochemical analysis of signal transduction pathways, FACS, in vitro immunological assays.
Hölzl MA, Hofer J, Kovarik JJ, Roggenbuck D, Reinhold D, Goihl A, Gärtner M, Steinberger P, Zlabinger GJ. The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I). Cell Immunol 267:88-93, 2011
Kovarik JJ, Tillinger W, Hofer J, Hölzl MA, Heinzl H, Saemann MD, Zlabinger GJ. Impaired anti-inflammatory efficacy of n-butyrate in patients with IBD. Eur J Clin Invest 41:291-8, 2010.
Hölzl MA, Gärtner M, Kovarik JJ, Hofer J, Bernheimer H, Sunder-Plassmann G, Zlabinger GJ. Quantification of α-galactosidase activity in intact leukocytes. Clin Chim Acta 411:1666-70. 2010