MedUni Vienna    Intranet    MedUni Vienna - Shop    University Library    Vienna General Hospital (AKH)  
 
phd_immunology.png
 
 
Hauptnavigation
  • Home
  • General Information
  • Research Laboratories
  • PhD Students
  • Lectures & Courses
 
PhD Immunologie / Research Laboratories / Günter STEINER, PhD
 
Subnavigation
  • Talin BARISANI-ASENBAUER, MD
  • Andreas BERGTHALER, DVM
  • Angelika BERGER, MD
  • Michael BERGMANN, MD
  • Christoph BINDER, MD, PhD
  • Barbara BOHLE, PhD
  • Kaan BOZTUG, MD
  • Heimo BREITENEDER, PhD
  • Michael DUCHENE, PhD
  • Adelheid ELBE-BÜRGER, PhD
  • Wilfried ELLMEIER, PhD
  • Michelle EPSTEIN, MD
  • Sabine FLICKER, PhD
  • Christina FORSTNER, MD
  • Elisabeth FÖRSTER-WALDL, MD
  • Erhard HOFER, PhD
  • Johannes HUPPA, PhD
  • Erika JENSEN-JAROLIM, MD
  • Renate KAIN, MD
  • Reinhard KIRNBAUER, MD
  • Alexander KIRSCHNER, PhD
  • Reinhard KLEIN, PhD
  • Sylvia KNAPP, MD, PhD
  • Herwig KOLLARITSCH, MD
  • Karl KUCHLER, PhD
  • Vladimir LEKSA, PhD
  • Birgit LINHART, PhD
  • Yan MA, MD
  • Diana MECHTCHERIAKOVA, PhD
  • Verena NIEDERBERGER-LEPPIN, MD
  • Rainer OBERBAUER, PhD
  • Rudolf OEHLER, PhD
  • Winfried F. PICKL, MD
  • Christian RADAUER, PhD
  • Marcus SÄEMANN, MD
  • Gernot SCHABBAUER, PhD
  • Wolfgang SCHREINER, PhD
  • Peter STEINBERGER, PhD
  • Günter STEINER, PhD
  • Christoph STEININGER, PhD
  • Karin STIASNY, PhD
  • Hannes STOCKINGER, PhD
  • Susanne VRTALA, PhD
  • Julia WALOCHNIK, PhD
  • Thomas WEICHHART, PhD
  • Thomas WEKERLE, MD
  • Ursula WIEDERMANN-SCHMIDT, MD, PhD
  • Gerhard J. ZLABINGER, MD


Inhaltsbereich

Günter Steiner, PhD

Professor of Biochemistry

Division of Rheumatology
Department of Internal Medicine III
Vienna General Hospital
Währinger Gürtel 18-20, 1090 Vienna, Austria


Phone: +43 (0)1 40400 - 43010
FAX: +43 (0)1 40400 - 43060


E-mail: guenter.steiner@meduniwien.ac.at

 

Research Interests
Pathogenesis of systemic autoimmune diseases, rheumatoid arthritis, autoantibodies, pathogenetic involvement of nucleic acid recognizing Toll-like receptors.


Pathogenetic mechanisms and diagnostic tools in rheumatoid arthritis

 

Abstract

Systemic autoimmune diseases are charactzerized by loss of tolerance to self components that are more or less ubiquituously expressed in an organ non-specific manner. Remarkably, the majority of the pathological autoimmune reactions are directed to proteins contained in nucleic acid bearing supramolecular complexes such as nucleosomes or spliceosomes. Our long-term research interest is to elucidate the molecular mechanisms leading to loss of tolerance to these structures with a particular focus on the role of nucleic acid recognizing Toll-like receptors, especially TLR7 and TLR9. Furthermore, the involvement of the disease associated MHC II molecule HLA-DR4 in the pathogenesis of rheumatoid arthritis is studied in some detail. For these investigations we are using inducible models of rheumatoid arthritis such as collagen-induced arthritis and pristane-induced arthritis as well as transgenic mouse strains expressing human HLA-DR4 and/or TNFα.
In addition to the animal studies, investigations in patients are carried out aimed at characterizing signatures of autoantibodies and other biomarkers in human sera that might allow to predict disease outcome and response to therapy.


Selected Publications

Biliavska I, Stamm TA, Martinez-Avila J, Huizinga TW, Landewè RB, Steiner G, Aletaha D, Smolen JS, Machold KP. Application of the 2010 ACR/EULAR classification criteria in patients with very early inflammatory arthritis: analysis of sensitivity, specificity and predictive values in the SAVE study cohort. Ann Rheum Dis 2013;72:1335-1341.

Herman S, Kny A, Schorn C, Pfatschbacher J, Niederreiter B, Herrmann M, Holmdahl R, Steiner G, Hoffmann MH. Cell death and cytokine production induced by autoimmunogenic hydrocarbon oils. Autoimmunity 2012; 45:602-11.

Hoffmann MH, Skriner K, Herman S, Baumann C, Steiner CW, Ospelt C, Meyer B, Gleiss A, Pfatschbacher J, Niederreiter B, Tuncel J, Zanoni G, Steiner G. Nucleic acid-stimulated antigen presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis. J Autoimmun. 2011; 36:288-300; 2011.

 
Print
 

Quick Links

 
-- Contact
-- Center for Pathophysiology, Infectiology and Immunology

-- Intranet Login
 
 

Featured

 
 
 
 
 
© MedUni Wien  | 
 Publishing information | Terms of use | Accessibility | Contact