Professor of Immunology
Department of Molecular Immunology
Institute of Hygiene and Applied Immunology
Center for Pathophysiology, Infectiology and Immunology
Kinderspitalgasse 15, 1090 Vienna, Austria
Phone: +43 (0)1 40160 - 33001
FAX: +43 (0)1 40160 - 933002
Signal transduction in immune cells, T cell and macrophage development.
Structure, function and signal transduction of surface receptors of T cells and antigen presenting cells
Our research interest in immunology is characterizing the structure, function and the underlying signal mechanisms of immunoregulatory surface receptors on T cells and antigen presenting cells.
The goal of these studies is to identify new targets for developing novel strategies to correct abnormal and unwanted immune reactions in immunological disorders and diseases.
Internationally well recognized are the investigations, which contributed to the understanding of how glycosylphosphatidylinositol (GPI)-anchored receptor proteins transduce signals across the plasma membrane.
These studies were fundamental for the identification and characterization of special membrane microdomains called lipid rafts, which are more and more confirmed to control initiation of signal transduction across the plasma membrane of cells.
More information about the various research projects can be found <here>
Forster, F., W. Paster, V. Supper, P. Schatzlmaier, S. Sunzenauer, N. Ostler, A. Saliba, P. Eckerstorfer, N. Britzen-Laurent, G. J. Schütz, J. A. Schmid, G. J. Zlabinger, E. Naschberger, M. Stürzl, and H. Stockinger. 2014. GBP-1 mediated interaction of the T-cell antigen receptor signaling with the cytoskeleton. J. Immunol. 192: 771.
Fuertbauer, E., J. Zaujec, P. Uhrin, I. Raab, M. Weber, H. Schachner, M. Bauer, G. J. Schütz, B. R. Binder, M. Sixt, D. Kerjaschki, and H. Stockinger. 2013. Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells. Immunol. Letters. 154: 31.
Leksa, V., K. Pfisterer, G. Ondrovicova, B. Binder, S. Lakatosova, C. Donner, H. B. Schiller, A. Zwirzitz, K. Mrvova, V. Pevala, E. Kutejova, and H. Stockinger. 2012. Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells. J. Biol. Chem. 287: 22450.
Leksa, V., R. Loewe, B. Binder, H. B. Schiller, P. Eckerstorfer, F. Forster, A. S. Cardona, G. Ondrovičová, E. Kutejová, B. R. Binder, and H. Stockinger. 2011. Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation. Circulation Res. 108: 676.