Professor of Child and Adolescent Medicine
Medical University Vienna
Department of Pediatrics
Vienna University of Technology
Institut of Chemical Engineering
Währinger Gürtel 18-20, 1090 Vienna, Austria
Phone: +43 (0)1 40400 - 32050
Autoimmune diagnostics, Innate immunity pathways, Diagnostics of pathomechanisms of iinfectious disorders in infants, inborn errors of infectious disorders.
Immunological mechanisms of neonatal bacterial infections
Basicly the main research lines are the search for improved diagnostic tools for the very EARLY diagnosis of severe infectious disorders (SIRS, Sepsis) in particularly premature infants based upon the immunological mechanisms of the innate immunity, and secondly the investigation of molecular immunological mechanism of the juvenile rheumatoid arthritis, the latter also in order to find an early diagnostic tool enabling specific therapies as early as possible.
Methodologically we try to establish improved separation techniques that allow the isolation and analysis of condensed protein complexes (circulating as well as tissue embedded) up to a MW of 700 kD and beyond.
All research efforts are directed towards a translational applicability.
Cimenti C, Erwa W, Herkner KH, Kasper DC, Müller W, Resch B: The predictive value of immature granulocyte count and immature myeloid information in the diagnosis of neonatal sepsis, Clin Chem Lab Med 2012; 50(8):1429–1432
Mechtler TP, Stary S, Metz TF, De Jesús VR, Greber-Platzer S, Pollak A, Herkner KR, Streubel B, Kasper DC: Neonatal screening for lysosomal storage disorders: feasibility and incidence from a nationwide study in Austria, Neonatal screening for lysosomal storage disorders: feasibility and incidence from a nationwide study in Austria, Lancet. 2012 Jan 28;379(9813):335-41
Kasper DC, Altiok I, Mechtler TP, Böhm J, Straub J, Langgartner M, Pollak A, Herkner KR, Berger A: Molecular Detection of Late-Onset Sepsis in Premature Infants Using Small Blood Volumes: Proof-of-Concept, Neonatology 103(4), 268-73 (2013)