Professor of Tropical Medicine
Institute of Specific Prophylaxis and Tropical Medicine
Center for Pathophysiology, Infectiology and Immunology
Kinderspitalgasse 15, 1090 Vienna, Austria
Phone: +43 (0)1 40160 - 38210
FAX: +43 (0)1 40160 - 938293
Molecular biology and biochemistry of protist parasites, mainly Entamoeba histolytica, Trichomonas vaginalis and Giardia intestinalis as well as Acanthamoeba spp. Genetic variation of Bordetella pertussis. Indoor allergy caused by insects.
Our long-term research interest is the chemotherapy of protist parasites.
One the one hand we are open to develop new approaches, so we had tested miltefosine and other alkylphosphocholines for the first time against pathogenic amoebae, and we examined new compounds isolated from tropical plants.
On the other hand a main goal ist to really understand, how the gold standard drug metronidazole acts against microaerophilic protists, why some get resistant, others do not, and what is exactly the chain of events leading to cell death.
The second project deals with structures of E. histolytica and their interaction with the human host. One abundant surface component is the proteophosphoglycan, a membrane-linked heavily O-glycosylated, phosphate-containing glycoprotein. Although this material has been studied for a long time, open questions about its structure and function remain which we plan to address.
Two additional smaller projects are to study the genetic variation of B. pertussis isolates found in Austria, and we are studying household moths as a cause of indoor allergies.
More information about the various research projects can be found <here>