Professor of Immunology
Division of Immune Receptors and T cell Activation
Institute of Immunology
Center for Pathophysiology, Infectiology and Immunology
Lazarettgasse 19, 1090 Vienna, Austria
Phone: +43 (0)1 40160 - 33242
FAX: +43 (0)1 40160 - 933201
T cell activation, Costimulation, Regulation of T cell Responses,Receptor-Ligand-Interaction.
Immune Receptors and T cell Activation
We are interested in the contribution of cell surface molecules (positive and negative costimulatory molecules) on human T cells and antigen-presenting cells (APC) in immune responses.
For our studies we have developed experimental systems that make it possible to efficiently analyse the contribution of individual ligands to T cell activation processes. Here our current focus is the development of systems that allow for studying the regulation of T cell responses to pathogen- and tumour antigens.
In addition we are trying to identify novel receptors and ligands that regulate the activation of T cells by APC.
To achieve this goal we rely on our experience in the generation, expression and screening of cDNA expression libraries.
1. A comprehensive and quantitative analysis of the major specificities in rabbit antithymocyte globulin preparations. Popow I, Leitner J, Grabmeier-Pfistershammer K, Majdic O, Zlabinger GJ, Kundi M, Steinberger P. Am J Transplant. 2013 Dec;13(12):3103-13. doi: 10.1111/ajt.12514. Epub 2013 Oct 29. PMID: 24168235 [PubMed - in process]
2. TIM-3 does not act as a receptor for galectin-9. Leitner J, Rieger A, Pickl WF, Zlabinger G, Grabmeier-Pfistershammer K, Steinberger P. PLoS Pathog. 2013 Mar;9(3):e1003253. doi: 10.1371/journal.ppat.1003253. Epub 2013 Mar 21. PMID: 23555261 [PubMed - indexed for MEDLINE] Free PMC Article
3. Costimulatory signals potently modulate the T cell inhibitory capacity of the therapeutic CD11a antibody Efalizumab. Kuschei WM, Leitner J, Majdic O, Pickl WF, Zlabinger GJ, Grabmeier-Pfistershammer K, Steinberger P. Clin Immunol. 2011 May;139(2):199-207. doi: 10.1016/j.clim.2011.02.007. Epub 2011 Feb 10. PMID: 21414849 [PubMed - indexed for MEDLINE]