Professor of Internal Medicine
University Clinic Internal Medicine III / Nephrology
Währinger Gürtel 18-20, 1090 Vienna, Austria
Phone: +43 (0)1 40400 - 43000
Cross-omics analyses of molecular regulation of renal allograft failure, alloimmuneresponse in clinical transplantation, bioinformatics, statistics of large molecular data sets, clinical application.
Systems biology of renal allograft failure
My lab has a longstanding interest and track record in the cross omics evaluation of renal allograft function and failure. Specifically, the molecular mechanisms of postischemic acute kidney injury (AKI) and cellular as well as humoral alloimmuneresponses in the clinical transplant setting have been studied extensively. Molecular candidates of AKI have been identified and studied in large randomized clinical trials in humans. We are currently elucidating the molecular effects of inhibition of some of the candidates as well as on the clinical outcomes of ARF.
Antisense oligonucleotides were designed based on the bioinformatics evaluations against leading clusters of miRNAs that have been identified as key regulators of these processes. Sophisticated bioinformatics as well as statistical analyses were and are designed and applied to uncover the broader effects of the molecular intervention.
The ultimate goal of our research is to pretreat the donor organ with our antisense candidates and reduce the rate of AKI, which remained unaltered over the last decades in the range of 25% in deceased donor transplantation. Our research is supported by FWF and EU grants.
Details about the lab may be found at www.muw.ac.at/nephrogene