Atherosclerosis; B-Lymphocytes; Cell-Derived Microparticles; Complement Factor H; Immunity; Immunity, Humoral; Inflammation; Lipid Peroxidation; Lipoproteins; Receptors, Oxidized LDL; Thrombosis
Techniques, methods & infrastructure
The laboratory space is located in the Anna Spiegel Research Building and is equipped with state-of-the-art infrastructure including cell culture facilities, a histology unit, a FACS-Calibur and Fortessa flow cytometers, a NanoSight instrument, Seahorse XF, chemiluminescent und fluorescent readers, a Biacore instrument, as well as standard infrastructure for molecular biology, biochemistry, immunology and cell biology techniques. A high-end flow activated cell sorting facility and an advanced imaging facility are available in the building. Murine atherosclerosis, vascular inflammation, and thrombosis models are established, and mice are bred in the in-house SPF animal facility. The principal investigator is also affiliated to the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences (www.cemm.oeaw.ac.at), which is located in the same building. CeMM facilities for world-class mass spectrometry and genomics, deep-sequencing, bioinformatics and chemical biology are available.