The main research interest of the group is the understanding and manipulation of processes involved into the regulation of T-cell responses with focus on regulatory T-cells. One main area is the definiton of so far undefined transcription factors and signaling pathways which shape the phenotype and function of regulatory T-cells. Furthermore, we also aim to modulate inhibitory signals in effector T-cells in order to provide novel strategies for the improvement of adoptive immunotherapies in cancer. A second major aim is the understanding of the interaction of commonly used prescription drugs with cells of the immune system. Currently, we are mainly focusing on potential immunomodulatory effects of different antibiotic compounds and slective-serotonine receptor inhibitors (SSRI) on CD4+ and CD8+ T-cells.
Techniques, methods & infrastructure
Cell culture, Molecular biology methods (molecular cloning, real time PCR), retroviral overexpression in primary human T-cells, ELISA, immunoblotting, multi-color flow cytometry (FACS), FACS-sorting